A study of prescribing patterns of antipsychotics in inpatients with Schizophrenia has found marked variations in prescribing patterns between countries (STT5). A study of Memantine as an adjunct in the treatment of schizophrenia has found no benefit on PANSS scores (STT5). Another study has found an association between lissencephaly genes and executive dysfunction in Schizophrenia and Bipolar Disorder (STT5).
The authors of a systematic review found that education delayed the onset of dementia (STT3). There is a discussion of the role of polyunsaturated fatty-acids in relation to aging of the brain in an article in the Journal of Nutrition. The interaction between anticholinesterase inhibitors and the circadian rhythm is discussed in a review article.
Learning Disability Psychiatry
A case-control study of 54 people with Cornelia de Lange syndrome and 46 control subjects looking at behavioural phenotypes found that severe autism (32.1% in Cornelia de Lange and 7.1% in the control group) and compulsive behaviour were significantly higher in the former group (STT3). In a postal questionnaire study of Phenylketonuria there were found to be 98 people in the survey who hadn’t been treated at birth, 50 of whom hadn’t been tried on a phenylalanine-restricted diet and the authors suggest a need for further research in this population (STT3).
There was also a South London And Maudsley randomised-control study looking at a specific self-help program for eating disorders which was CD-Rom based (although the authors point out that a web-based program has become available) in a group of people with Bulimia Nervosa or eating disorder not otherwise specified (NOS). There was found to be no significant difference in bingeing or vomiting between the self-help and waiting list groups (STT5).
86 people (with 78 followed up) with 2/9 DSM-IV criteria for Borderline Personality Disorder and 78 also (with the same criteria fulfilled) were allocated to CAT and ‘good clinical care’ respectively. While there was no difference in a number of outcome measures those with CAT attained those outcomes more quickly – the authors recommend larger studies (STT5).
In the British Journal of Psychiatry, there is an editorial on grief and acceptance looking at cognitive and emotional acceptance and calling for further research in this area and there is also a very interesting editorial by Peter Tyler who converts findings from some of the studies in the December issue into a series of statements with supporting arguments. This certainly helps in organising the many complex topics that are covered in each issue . The interesting question of whether acceptance should be a goal of treatment in terminal illness was also raised (STT5). A Swedish cohort study of just under 1 million male military recruits with IQ measurements at entry into the study and follow-up over 2 decades found that higher IQ was associated with lower risk of homicide even after adjusting for various confounders but the authors recommend replication studies (STT5). There is also an interview with Steve Peters psychiatrist and trainer for the British Olympic Cyclists in the Times. In a study of 11578 consecutive psychiatric admissions to a tertiary referral service in Barcelona, there was found to be significantly lower in immigrants than in indigenous people and that there was a markedly lower rate in immigrants from Asian and Sub-Saharan immigrants (STT3).
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