In the 4th edition of the news review associations with conversion to schizophrenia are identified and a study finds a high reversion from vascular cognitive impairment non-dementia.
A post-mortem study in people with Huntington’s Disease has found a significant reduction in hypocretin-1 neurons compared to controls in the prefrontal cortex and CSF although the clinical significance is unclear (STT5). In a post-mortem study (open-access article) of people with Alzheimer’s Disease or mild cognitive impairment, the authors concluded that when the disease is widespread that agreement between pathologists is good but in the initial stages of the disease there is a need for standardisation of the sampling method and also a need for two pathologists to confirm the results (STT2*). 45% of people with vascular cognitive-impairment non-dementia reverted in this 1-year follow-up study.
A study funded by a number of pharmaceutical companies and presented in an open-access paper has found that a partial dopaminergic agonist Bifupronex (20mg) significantly reduced total PANSS scores in people with schizophrenia compared with a placebo group in this 6/52 double-blind placebo-controlled trial (STT4). Ultra-high risk of conversion to schizophrenia was associated with metabolic processing in the corpus callosum and in another study with the structure of the anterior cingulate cortex (STT4).
A meta-analysis of non-pharmacological treatments for cancer-related fatigue has found that both exercise and a range of psychological interventions are roughly similar in their benefits (STT2). A qualitative study of 13 studies of brain injury found that there were no differences in functional outcome between men and women with moderate to severe brain injury (STT1). 33% of 66 patients initially diagnosed with Parkinson’s Disease had the diagnosis changed during the follow-up period and this resulted for instance from new developments in the presentation during the follow-up period.
* The treatment in this case is related to the possibility of genetic testing on confirmation of the diagnosis.
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