Podcast Review

The podcast reviewed here is the April edition of the American Journal of Psychiatry Podcast freely available here (you might need to use a program such as iTunes to access the podcast). The subjects covered in this edition include amongst other topics post-partum psychosis, a five factor model for personality disorder, the genetics of schizophrenia and autism. The post-partum psychosis discussion is focused around a tragic case-study and a markedly increased rate of post-partum psychosis with bipolar disorder is also noted. There is a report on a study investigating a five-factor model of personality disorder. A number of mental health professionals were asked to assess cases (from each of the 3 personality clusters) using the model (and comparative approaches) and were also asked to assess the utility of the approach. The rate of detecting cases using the five-factor model was 47% which was significantly lower than by using the DSM-IV criteria.  This type of study is important because in the next edition of DSM consideration is being given to the use of a dimensional approach. This type of debate – categorical versus dimensional approaches is occuring across a range of diagnoses as completion of the next revision of DMS approaches. Linkages for schizophrenia were examined in another study which found a suggestive linkage on chromosome 17q21 as well as 15q. An association was also reported in a Canadian study between schizophrenia and schizoaffective disorder and the Nitric Oxide Synthase 1 adaptor protein gene using single nucleotide polymorphisms. They used a statistical technique referred to as posterior probability in which the researchers take study data and use this to refine a ‘prior’ probability for a phenomenon. When they found significant relationships, they then examined the expression of the allele in post-mortems of people with schizophrenia. Having a study which traverses many domains of knowledge as well as using new statistical approaches is interesting as are the findings of an association with the NOS gene.


If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk


The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.


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