Research in Psychosis
In a study in which two psychiatrists assessed 100 inpatients, the diagnosis of schizophrenia was found to occur more frequently when using ICD-10 criteria compared DSM-IV and the researchers suggest that this might be due to the absence of an exclusion of an affective syndrome in ICD-10 (although there are references to affective symptomatology in ICD-10)(Cheniaux et al, 2009). In a longitudinal structural MRI study, people with schizophrenia were divided into good and poor outcome groups and in the latter group there was found to be a significant assocation with reduction in the volume of the putamen (Mitelman et al, 2009). In an 18-week double-blind flexible dosing study (n=147) of Clozapine and Ziprasidone in people with treatment-resistant schizophrenia the researchers concluded that both medications showed similar efficacy with reduction in PANSS scores being the primary outcome measure (Sacchetti et al, 2009).
In a study of residents in long-term care who were referred for psychiatric assessment (n=868) there was found to be elevated Thyroid Stimulating Hormone (TSH) in 10.8% of people and a significant association of elevated TSH with female gender (Sabeen et al, 2009).
News in Brief
In a recent poll by the Royal Pharmaceutical Society of 457 people over the age of 65, just under half of respondents reported that they were taking 5 or more medications and 60% thought that they were experiencing adverse side-effects. There has been a suggestion of closer monitoring of antipsychotic initiation in older adults with diabetes following the results of a longitudinal study of 13,817 older adults (>65 years) who had commenced antipsychotics and finding that compared to a group who had stopped antipsychotic medication 180 days previously there was an elevated prevalence of hyperglycaemia. In a recent poll of 2000 people over the age of 16, there were found to be gaps in knowledge in the respondents in areas of potential importance – for instance 26% of respondents did not think there were approaches to reducing their risk of developing dementia.
Cheniaux E, Landeira-Fernandez J, Versiani M. The Diagnoses of Schizophrenia, Schizoaffective Disorder, Bipolar Disorder and Unipolar Depression: Interrater Reliability and Congruence between DSM-IV and ICD-10. Psychopathology. 2009 Jul 16;42(5):293-298. [Epub ahead of print].
Mitelman SA, Canfield EL, Chu KW, Brickman AM, Shihabuddin L, Hazlett EA,Buchsbaum MS.Schizophr Res. 2009 Jul 16. [Epub ahead of print]. Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen.
Sabeen S, Chou C, Holroyd S.Abnormal thyroid stimulating hormone (TSH) in psychiatric long-term care patients.Arch Gerontol Geriatr. 2009 Jul 16. [Epub ahead of print].
Sacchetti E, Galluzzo A, Valsecchi P, Romeo F, Gorini B, Warrington L; MOZART Study Group.Schizophr Res. 2009 Aug;113(1):112-21.Ziprasidone vs clozapine in schizophrenia patients refractory to multiple
antipsychotic treatments: the MOZART study.
You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast).
If you have any comments, you can leave them below or alternatively e-mail firstname.lastname@example.org
The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.