- There is a small 6-week study (n=54) in the Journal of Clinical Psychiatry examining the use of valproic acid in people with Bipolar Disorder I or II depression. This is a double-blind randomised placebo controlled trial with the valproic acid group associated with 38.5% v 10.7% (placebo) of subjects meeting response criteria (p=0.017 0.17). Depression was assessed using the MADRS although the difference in remission rates (rather than response criteria) has a p-value of 0.208.
- Current Directions in Psychological Sciences have an open access edition focusing on Schizophrenia here while there is an open-access review of Aripiprazole in the treatment of late-onset schizophrenia here.
- Percentage thickness changes in the inferior temporal and right fusiform cortices at six-months were associated with reduction in memory performance in this relatively small study (n=142) of older adults.
- There is a review article here on the three newly classified variants of primary progressive aphasia.
- Diffuse Tensor Imaging was useful in discriminating between amnestic Mild Cognitive Impairment (MCI) and non-amnestic MCI in this moderately sized study (n=418).
- A structural 3T MRI study (n=50) examining age associated changes in the hippocampus identified these changes in the subiculum but found no evidence in other subfields.
- CSF levels of Beta-Amyloid were inversely associated with years of education in this study which recruited 70 people with a diagnosis of Alzheimer’s Disease.
- Links between DISC1 and APP gene products were identified in this study. The write-up is very good and essentially this research suggests a link between genes associated with Schizophrenia and Alzheimer’s Disease respectively. The functional links were identified in a neurodevelopmental model and involve interactions of the gene products during migration of neurons. On the basis of their findings the researchers hypothesise that the Amyloid Precursor Protein (APP) acts as a scaffold that interacts with the DISC-1 protein to facilitate migration. The role of the APP in Alzheimer’s Disease is different and so this study is not suggesting a link between the diseases although it is becoming clear that these two proteins have important biological functions.
- Mind Hacks has another round-up of Spike Activity here and also has a book in the pipeline which I’m sure will be well worth looking out for.
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