The authors of a systematic review in the Journal of Neurology, Neurosurgery and Psychiatry concluded that MRI determined white matter hyperintensities had heterogenous pathological correlates and that developing quantitative MRI methods could enhance yield of clinical data.
The International Working Group for New Research Criteria for the Diagnosis of Alzheimer’s Disease (AD) have published a paper in the Lancet Neurology in which they propose broader criteria for diagnosis in the research setting.
A small study produced no evidence of an association between AD-related olfactory deficits and Amyloid Beta load using PET with Pittsburgh B compound.
There is an interesting case study describing cobalamin deficiency associated executive dysfunction improving with replacement therapy.
A group in China investigated the possible role of the cerebellum in mild cognitive impairment. They compared 26 people with amnestic Mild Cognitive Impairment with 18 controls. Both groups underwent resting state fMRI at baseline and follow-up (at least 20 months later). Those with aMCI were significantly more likely to exhibit a higher amplitude of low frequency variation in the posterior cerebellum. The cerebellum has received little attention relative to cortical areas in MCI and it would be interesting to see further work in this area.
There is a write-up of a Nature Medicine study involving post-mortem whole-genome tissue scans in 21 people who had been diagnosed with depression and 18 controls and finding a 2-fold increase in the MKP-1 gene product in the brains of the depressed group. MKP-1 has associations with neuronal survival.
There is a write-up of a Nature paper in which a research group demonstrated a change in Blood Brain Barrier permeability using pharmacological modification of pericytes.
Vaughan Bell has another episode of Spike Activity at Mind Hacks in which amongst other items he links to an article on the default mode network – a network in the brain with many functional associations as well as a link to a piece on 50 psychology studies.
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