News Round-Up: October 2010 3rd Edition

The authors of a systematic review in the Journal of Neurology, Neurosurgery and Psychiatry concluded that MRI determined white matter hyperintensities had heterogenous pathological correlates and that developing quantitative MRI methods could enhance yield of clinical data.

The International Working Group for New Research Criteria for the Diagnosis of Alzheimer’s Disease (AD) have published a paper in the Lancet Neurology in which they propose broader  criteria for diagnosis in the research setting.

A small study produced no evidence of an association between AD-related olfactory deficits and Amyloid Beta load using PET with Pittsburgh B compound.

There is an interesting case study describing cobalamin deficiency associated executive dysfunction improving with replacement therapy.

A group in China investigated the possible role of the cerebellum in mild cognitive impairment. They compared 26 people with amnestic Mild Cognitive Impairment with 18 controls. Both groups underwent resting state fMRI at baseline and follow-up (at least 20 months later). Those with aMCI were significantly more likely to exhibit a higher amplitude of low frequency variation in the posterior cerebellum. The cerebellum has received little attention relative to cortical areas in MCI and it would be interesting to see further work in this area.

There is a write-up of a Nature Medicine study involving post-mortem whole-genome tissue scans in 21 people who had been diagnosed with depression and 18 controls and finding a 2-fold increase in the MKP-1 gene product in the brains of the depressed group. MKP-1 has associations with neuronal survival.

There is a write-up of a Nature paper in which a research group demonstrated a change in Blood Brain Barrier permeability using pharmacological modification of pericytes.

Vaughan Bell has another episode of Spike Activity at Mind Hacks in which amongst other items he links to an article on the default mode network – a network in the brain with many functional associations as well as a link to a piece on 50 psychology studies.

Index: An index of the site can be found here. The page contains links to all of the articles in the blog in chronological order. Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

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