There is a recent review article on Frontotemporal Lobar Degeneration by Rabinovici and Miller freely available here. The authors have produced a comprehensive review on Frontotemporal Lobar Degeneration but I was particularly interested in the epidemiology section which is examined here. The section is just a few paragraphs long but covers the following
- Age of onset
- Sex Distribution
- Median Survival
Throughout the review article, the authors have considered three types of FTLD – behavioural-variant FTD, semantic dementia and progressive non-fluent aphasia. The prevalence and incidence data shows fairly narrow limits but there also look to be relatively few studies. Researchers such as Neary, Hodges, Dawson and Gustafson figure prominently in the research cited in this area. Although commonly thought of as an early-onset form of dementia, the authors cite research suggesting that up to 1/4 of FTD presentations occur in those over the age of 65. The authors cite evidence suggesting that progressive non-fluent aphasia occurs predominantly in females while the reverse is true for the other two forms. Survival times for the different subtypes of FTLD seem to differ between studies and perhaps large studies are needed in this area.
The review is well structured and draws some useful conclusions that can usefully inform clinicians and researchers.
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