In a short report titled ‘A diverse portfolio of novel drug discovery efforts for Alzheimer’s disease: Meeting report from the 11th International Conference on Alzheimer’s Drug Discovery, 27-28 September 2010, Jersey City, NJ, USA’ (freely available here), authors Lee and colleagues outline new developments in Alzheimer’s Disease drug therapies. These developments are all at the research stage and so it may be some time before we see them used clinically if they are successful. The authors essentially highlight areas of interest in the conference and their report is broadly divided into biomarkers, targetting Amyloid-Beta pathology, neuroprotection/cognitive enhancement and frontotemporal dementia/tauopathies. In terms of biomarkers, the authors summarise new approaches including metabolomics and immunosignatures as well as quality control in all stages of data management. For the targetting of Beta-Amyloid pathology the authors mention talks on β-secretase and γ-secretase enzymes, RAGE and fibrinogen. Neuroprotective and cognitive enhancement strategies are varied and ultimately will depend on the clinical trials. The authors mention allopregnanolone, cAMP responsive element-binding protein and Sildenafil, hippocampal hyperexcitability and levetriacetam as well as blocking Aβ oligomer binding to neurons amongst other strategies. Finally in terms of frontotemporal dementia and the tauopathies the authors mention mitoxantroneantisense nucleic acid tag and
phosphatase 2A. The field is so complex that the report represents a ‘snapshot of a snapshot’ of the current research in the field of dementia. Nevertheless this highly structured report offers a framework on which to extend an understanding of additional strategies into dementia diagnosis and treatment.
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