Novel Drug Discoveries in Alzheimer’s Disease

In a short report titled ‘A diverse portfolio of novel drug discovery efforts for Alzheimer’s disease: Meeting report from the 11th International Conference on Alzheimer’s Drug Discovery, 27-28 September 2010, Jersey City, NJ, USA’ (freely available here), authors Lee and colleagues outline new developments in Alzheimer’s Disease drug therapies. These developments are all at the research stage and so it may be some time before we see them used clinically if they are successful. The authors essentially highlight areas of interest in the conference and their report is broadly divided into biomarkers, targetting Amyloid-Beta pathology, neuroprotection/cognitive enhancement and frontotemporal dementia/tauopathies. In terms of biomarkers, the authors summarise new approaches including metabolomics and immunosignatures as well as quality control in all stages of data management. For the targetting of Beta-Amyloid pathology the authors mention talks on β-secretase and γ-secretase enzymes, RAGE and fibrinogen. Neuroprotective and cognitive enhancement strategies are varied and ultimately will depend on the clinical trials. The authors mention allopregnanolone, cAMP responsive element-binding protein and Sildenafil, hippocampal hyperexcitability and levetriacetam as well as blocking Aβ oligomer binding to neurons amongst other strategies. Finally in terms of frontotemporal dementia and the tauopathies the authors mention mitoxantroneantisense nucleic acid tag and
phosphatase 2A. The field is so complex that the report represents a ‘snapshot of a snapshot’ of the current research in the field of dementia. Nevertheless this highly structured report offers a framework on which to extend an understanding of additional strategies into dementia diagnosis and treatment.

Index: An index of the site can be found here. The page contains links to all of the articles in the blog in chronological order. Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

One comment

  1. This book gently and wisely guides people facing early Alzheimer’s in the same respectful manner as those facing anything else — arming them with well-grounded knowledge and practical coping strategies. This is a thorough, very readable, and most useful resource…..
    Robyn Yale, LCSW
    Clinical Social Worker and author of “Developing Support Groups for Individuas with Early Stage Alzheimer’s Disease: Planning, Implementation, and Evaluation”


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