A large prospective trial (n=660) of combination antidepressants versus monotherapy as a first-line treatment for depression provided evidence during the 7-month follow-up period that the two combination treatments were just as effective as monotherapy in this study. However only two combinations were examined and combination therapy is not usually considered as first-line treatment in various guidelines.
The Department of Health have published their action plan for implementing the National Dementia Strategy which is available here and also published their Dementia Commissioning pack which is available here.
In a moderately sized study (n=78) people with Mild Cognitive Impairment (MCI) and a cognitively intact control group were randomised to either a Growth Hormone Releasing Hormone analogue Tesamorelin (subcutaneously) or placebo over a 20-week period. The researchers found that the Tesamorelin group experienced higher subjective cognitive improvement and higher scores on executive and verbal memory tasks than the placebo group. It will be interesting to see the results of further replication studies involving other populations and longer follow-up periods.
The long-term consequences of Traumatic Brain Injury was discussed at the Alzheimer’s Association International Conference (AAIC) in the USA and research was presented associating TBI with subsequent dementia although the relationship is complex.
There is an interesting article on Medically Unexplained Symptoms illustrated with cases and diagnostic algorithms available here.
There is a write-up of preliminary findings with Leviteracetam in people with Alzheimer’s Disease but there will need to be larger replication studies.
The draft DSM-V criterion for a mixed depressive episode are being expanded to fit more closely with clinician’s experience and there are further details here.
A new analysis of the Laetoli footprints suggest that human ancestors started walking upright some 3.7 million years ago.
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