Brodmann Area 8

Derived from Gray’s Anatomy 20th Edition 1918 Lithograph Reproduction, Public Domain

This is a brief literature review covering articles on Brodmann Area 8. A search was conducted in medline using the term ‘Brodmann Area 8’. The Frontal Eye Fields were not identified in Brodmann Area 8 in this fMRI study (article freely available here) and it is interesting to consider this further in the interpretation of other studies as a possible area of controversy. The authors of one paper (freely available here) describe the Medial Prefrontal Cortex, constituting Brodmann Areas 8 and 9 as an area which plays a role in music-evoked autobiographical memories. In this freely available article, the researchers examined a case series of people with lesions in the Superior Frontal Gyrus and hypothesised on the basis of their results that the Superior Frontal Gyrus was involved in working memory and that the left Superior Frontal Gyrus is involved in spatial processing amongst other findings. Coherent movements in the visual field were found to activate the Frontal Eye Fields (which the researchers describe as equivalent to Brodmann Area 8 ) in this PET study. Uncertainty was associated with Brodmann Area 8 in this fMRI study. Maximal binding and affintity of glutamate receptor subtypes was found in Brodmann Area  8 in this post-mortem study. A recently developed approach to localising brain activity on the basis of analysis of EEG activity (electroctomography) identified the Left Frontal Gyrus as manifesting increased activity following a period of treadmll activity in 22 runners.

Brodmann Area 8 has been studied in relation to a number of illnesses. In an fMRI study of a small group of chronic tinnitus patients, the Superior Frontal Gyrus was one of a number of areas showing an increase in activity in a binaural discrimination task when compared to controls. In a small PET study increased activity in a number of areas including Brodmann Area 8 were identified in subjects with Idiopathic Torsion Dystonia in comparison with controls. The groups were assessed whilst at rest and while playing a console game which involved the use of a joystick. In a case study the researchers identified an infarct interrupting the connections between the Basal Ganglia and the Left Superior Frontal Gyrus and associated with persisting executive dysfunction. An increase in Galanin was found in Brodmann Area 8 in subjects with Alzheimer’s Disease in comparison with a control group in this post-mortem study. In this post-mortem gene expression study, researchers identified a relatively large number of genes which were downregulated in Alzheimer’s Disease and Schizophrenia and which were distinct from the control sample. Grey matter reduction in the superior frontal gyrus differentiated subjects with schizophrenia with negative symptoms during periods of clinical stability from subjects with schizophrenia without negative symptoms during periods of clinical stability in this small study. The researchers in this fMRI study describe the dorsolateral prefrontal cortex as including Brodmann Areas 8 and 9 and identified increased activity in subjects in these areas in a delayed response task. Reduced cerebral blood flow was identified with aging in a number of areas including Brodmann Area 8 in subjects with Schizophrenia in this PET study. Standing with eyes closed activated Brodmann Area 8 in this PET study.

 Appendix – Articles Reviewed in relation to Brodmann Areas or other Structures

Brodmann Area 1 – Somatosensory Cortex

An Investigation of D3 Receptors and Brodmann Area 1 in Schizophrenia

YouTubing the Somatosensory Cortex

Brodmann Area 2 – The Primary Motor Cortex

Brodmann Areas – Part 2: Area 4. The Primary Motor Cortex – A Brief Literature Review

YouTubing the Motor Cortex

Brodmann Area 6 (Agranular Frontal Area 6)

FDG-PET, Frontal Dysfunction and Mild Cognitive Impairment

Brodmann Area 6 – Premotor Cortex and the Supplementary Motor Area

YouTubing Brodmann Area 6

Brodmann Areas 5 and 7 (Somatosensory Association Cortex)

Brodmann Areas 5 and 7 (Somatosensory Association Cortex)

Brodmann Areas 13 and 14 (Insular Cortex)

What does the Insular Cortex Do Again?

Insular Cortex Infarction in Acute Middle Cerebral Artery Territory Stroke

The Insular Cortex and Neuropsychiatric Disorders

Developing a Model of the Insular Cortex and Emotional Regulation Part 1

Developing a Model of the Insular Cortex: A Recap

The Relationship of Blood Pressure to Subcortical Lesions

Pathobiology of Visceral Pain

Interoception and the Insular Cortex

A Case of Neurogenic T-Wave Inversion

Video Presentations on a Model of the Insular Cortex

MR Visualisations of the Insula

The Subjective Experience of Pain*

How Do You Feel? Interoception: The Sense of the Physiological Condition of the Body

How Do You Feel – Now? The Anterior Insula and Human Awareness

Role of the Insular Cortex in the Modulation of Pain

The Insular Cortex and Frontotemporal Dementia

A Case of Infarct Connecting the Insular Cortex and the Heart

The Insular Cortex: Part of the Brain that Connects Smell and Taste?

Stuttered Swallowing and the Insular Cortex

Brodmann Area 15 (Anterior Temporal Lobe – Controversial Area in Humans)

Review: The Anterior Temporal Lobes and Semantic Memory

Brodmann Area 25 – Anterior Cingulate Cortex

Brodman Areas Part 3. Brodmann Area 25 – The Anterior Cingulate Cortex

Brodmann Area 27 (Piriform Cortex)

Anosmia in Lewy Body Dementia

Brodmann Area 28  (Entorhinal Cortex)

MRI Measures of Temporoparietal Atrophy During Prodromal Alzheimer Disease*

Brodmann Areas 45, 46, 47 (Inferior Frontal Gyrus)

Which Bit of the Brain Detects the Emotions in Speech?

Medial Temporal Lobe

The Medial Temporal Lobe and Recognition Memory


Review: Differences in Hippocampal Metabolism Between Amnestic and Non-Amnestic MCI Subjects

Anatomy of the Hippocampus

Review: Involvement of BDNF in Age-Dependent Alterations in the Hippocampus

Miscellaneous Subcortical Structures

Book Review: Subcortical Vascular Dementia

Review: Subcortical Vascular Ischaemic Dementia

Review: Psychiatric Disturbances in CADASIL

Review: Cognitive Decline in CADASIL

Review: Relationship Between 24-hour Blood Pressure, Subcortical Ischemic Lesions and Cognitive Impairment

Hypocretin and Neurological Disorders

A Case of Pontine and Extrapontine Myelinolysis with Catatonia

Generic Articles Relating to Localisation

A History of Human Brain Mapping

Book Review: Brain Architecture

Brain Folding and the Size of the Human Cerebral Cortex

An index of the site can be found here. The page contains links to all of the articles in the blog in chronological order. Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

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