Whatever Happened to Brodmann Area 27?

Brodmann Area 27, by was_a_bee, adapted from Brodmann (1909), Public Domain

The brain is a complex structure and but can be organised according to several principles. One approach is to characterise the brain regions according to the microscopic properties of these regions.  More specifically the neurons are organised differently between regions. Some regions may contain unique types of neurons. This approach to understanding the organisation of the brain was proposed by the German Neuropathologist Korbinian Brodmann and resulted in the eponymously named Brodmann Area. There are 52 areas in all and I have covered other Brodmann Areas elsewhere. One area which was a little different from previous areas was Brodmann Area 27.  I undertook a search on Medline using the terms “BA27” and “Brodmann Area 27”. At the time of writing these searches returned 16 and 42 results respectively. The only relevant studies were this one making references to cytoarchitectural properties of BA27 (as well as other areas) and this post-mortem study in which the researchers found increases in [3H] Nicotine binding in BA27 in smokers.

According to the Sylvius Neuroanatomical Reference, BA27 includes areas CA1-CA4 of the Hippocampus and according to RadLex, BA27 is synonymous with the Presubicular Area. Using these terms in Medline would produce a large set of results numbering in the hundreds of thousands. However the point is not that the search terminology is wrong but rather that BA27 has been abandoned in the research literature in favour of these other terms.


Neuroanatomy Resources

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.


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