I came across this Scientific American Blog article via a Scientific American tweet (the Scientific American tweets reach over 356,000 people). The article is titled ‘Trouble at the Heart of Psychiatry’s Revised Rule Book’. The author University of Toronto History Professor Edward Shorter challenges the Diagnostic Statistic Manual classifications of three common mental illnesses – Major Depressive Disorder, Bipolar Disorder and Schizophrenia. I will address the author’s arguments against each in turn. However before doing so it is necessary to explain what a diagnostic system means and how it relates to science.
A diagnostic system is a system for classifying illnesses. DSM-V is the American Psychiatric Association’s classification system for mental illnesses. Psychiatry is a branch of Medicine which in turn is a branch of Science. Nevertheless as well as being a branch of Science, Psychiatry also involves the application of Science which is Technology. Let us look at some definitions of technology.
Dictionary.com: ‘The application of practical sciences to industry or commerce‘
Merriam-Webster: ‘The practical application of knowledge especially in a particular area‘
Oxford Dictionaries: ‘The application of scientific knowledge for practical purposes, especially in industry‘
The above definitions support the understanding of technology as the practical application of a body of knowledge including scientific knowledge. Diagnostic systems are a guide to aid practitioners in the practical application of a body of scientific knowledge and can therefore be described as a technology which complements a corresponding body of scientific knowledge*. This relationship is illustrated in the diagram below.
Once Psychiatry research and diagnostic systems are conceptualised in this way, it becomes much easier to understand the issues that Professor Shorter raises in his article. Throughout the article Shorter refers to diagnostic categories as artifacts and presumably is implying that they are errors. I will now address the arguments raised by Professor Shorter against 3 common mental illnesses and demonstrate that his arguments are erroneous.
1. Major Depressive Disorder. The author’s argument against Major Depression is that it was constructed as a political maneouvre which resulted in the amalgamation of two distinct types of depression which he recommends the authors of DSM-V should reconsider. I will address the two parts of the argument.
a. Shorter argues that the current diagnosis of Major Depression contains an amalgamation of two distinct illnesses – Melancholia and Non-Melancholia which are also identified as Endogenous and Reactive Depression. This distinction certainly is possible and it would be clinically useful. There is an underlying body of scientific knowledge which supports the construct of an illness referred to as Depression. There is also evidence to support Melancholic and Non-Melancholic forms of Depression. Interestingly though, Shorter doesn’t cite the relevant literature to support his case.
However there is also evidence against using this distinction. For instance Reactive Depression is considered to be a response to an external life event in contrast with Endogenous (Melancholic) Depression. However Bebbington and colleagues found in their study that cases of Endogenous Depression were just as likely to be preceded by life events as were cases of Reactive Depression (Bebbington et al, 1988). Furthermore Brown and Harris in landmark research characterised the relationship between chronic stressors and the onset of Depression (Brown and Harris, 1978). This research led to the creation of a vulnerability model of Depression. In this model a person will have a vulnerability to developing Depression which is then precipitated by life events.
We can now see that as well as a case for Melancholic and Non-Melancholic Depression there is a body of scientific knowledge which does not support this distinction. This is the science but what about the technology? The DSM-V committee must meet and use the body of scientific knowledge to make practical decisions about the diagnostic categories that will be used. Even at this stage, reliability data for diagnostic categories is just emerging from recent studies which the committee will consider in their deliberations. The emphasis though is on deciding what use to make of this body of scientific knowledge. These decisions are made within expert committees and are decisions made within the profession although incorporating expertise from other disciplines. From the discussion above, this is the application of scientific knowledge or technology which is distinct from the scientific process.
b. Shorter argues that Major Depression combines two distinct illnesses as a ‘political maneouvre’ and attributes this to an individual. However the same combination of Melancholic and Non-Melancholic features are also incorporated in the Depression criteria in the World Health Organisation’s ICD-10 Classification of Mental and Behavioural Disorders which is another popular diagnostic system.
In conclusion, Shorter recognises that the body of scientific knowledge supports the case for a Melancholic/Non-Melancholic distinction. That is the science. From there though, Shorter moves onto the technology and disagrees with the decision made by the expert consensus body when applying their knowledge of the scientific literature. In other words, Shorter who is not a member of the profession, disagrees with the decision taken by an expert consensus group of professionals to determine the contents of their profession’s diagnostic system. This is a separate matter from the science. The profession is backed up by a body of science which they have referenced in arriving at the diagnostic category. This body of science is the area that Shorter should have addressed but avoided citing at all.
In his discussion of Schizophrenia, after referring to this as an artifact he then proceeds to state that
‘Schizophrenia is nothing more than a synonym for chronic psychosis’
However nothing could be further from the truth. A careful inspection of the DSM-IV criteria reveals that there are several subtypes and course specifiers including ‘Episodic with Interepisode Residual Symptoms’ and ‘Single Episode in Full Remission’. In other words, the current DSM-IV diagnostic category for Schizophrenia allows for both remission as well as other courses of the illness with varying outcomes. Shorter follows on from this by suggesting that people with adolescent onset psychosis ‘can hold undemanding jobs’. However the researchers in this study for instance conclude that
‘This study challenges the findings of a larger and older literature base consisting primarily of non-comparative studies concluding that teenage onset indicates a poor outcome’
Indeed Shorter’s suggestion about people with adolescent onset psychosis is an example I think of the way in which diagnostic labels can be misused. Psychiatrists realise that diagnostic labels are tools and that people use these labels in different ways. Psychiatrists intend that diagnostic labels as used as a framework for dialogue, research and treatment not as a label that will ensure a person is compartmentalised into a restricted role within society.
3. Bipolar Disorder. Shorter refers to Bipolar Disorder as
‘the third flaw’
and that this
‘assumes that the Depression of Unipolar Disorder…is different from Bipolar Depression’
and further that
‘there are no natural disease entities called Bipolar Depression and Unipolar Depression’
Shorter’s description of Bipolar Disorder as ‘the third flaw’ is strong language. If the arguments for Major Depression are used here then it can be argued that this is a remark about the DSM-V committee’s decisions and again that process is distinct from the science. His qualifiers for this assertion are easily challenged. All that is needed is to find evidence that Bipolar Depression and Unipolar Depression are distinct and that there is evidence that these are ‘natural disease entities’.
Goodwin and Jamison concluded in their assessment of the research literature that Bipolar Depression and Unipolar Depression were indeed distinct but restricted their analysis to a comparison of Bipolar I Depression and Unipolar Depression (Goodwin and Jamison, 2007). Here they state that
‘The most widely replicated studies point to a picture of the bipolar-I depressed patient as having more mood lability, psychotic features, psychomotor retardation and comorbid substance abuse. In contrast, the typical unipolar patient in these studies had more anxiety, agitation, insomnia, physical complaints, anorexia and weight loss‘ (Goodwin and Jamison, 2007)
Goodwin and Jamison cite a considerable body of research literature to support their conclusions. Shorter does not comment on the distinction between Bipolar I and II Depression or even on Hypomania and Mania. With regards to these being ‘natural disease entities’ it is difficult to know what exactly Shorter means by this. For instance if he means that there is an illness which is independent of socialcultural factors then there is an abundance of evidence of manic illnesses occurring throughout history (when referring to Bipolar Depression in which the Depression may follow on from an episode of Mania). As an example in 1812 Rush writes
‘Its premonitory signs are, watchfulness, high or low spirits, great rapidity of thought, and eccentricity in conversation, and conduct; sometimes pathetic expressions of horror, excited by the apprehensions of approaching madness; terrifying or distressing dreams; great irritability of temper; jealousy, instability in all pursuits; unusual acts of extravagance, manifested by the purchases of houses, and certain expensive and unnecessary articles of furniture, and hostility to relations and friends‘ (Rush, 1812)
Other descriptions date back as far as Cappadocia in 150 AD (Jellife, 1931) and continue into the present detailing the common characteristics of manic episodes. Shorter then goes on to suggest that
‘the entire concept of Bipolar Disorder has been a gift to the pharmaceutical industry’
and claims that patients are
The point about the Pharmaceutical Industry is irrelevant to the title and stated aims of the article and when used in conjunction with the phrase about inappropriate treatment suggests that the author finds flaws not only with the diagnostic categories but also with the treatment and ends up making a blanket statement without so much as a single citation to the scientific literature. Shorter then goes onto to say
‘There has been almost no progress in psychopharmacology over the last thirty years’
In my opinion, this statement is so ridiculous that is of almost no value and successfully rebutting this statement is trivially simple. I will give just a single example. The Acetylcholinesterase inhibitors have been shown to slow the progression of Alzheimer’s Disease. Research in this area has progressed at a rapid pace. A quick search of Medline using a filter to restrict the dates of returned articles reveals that in the past 30 years there have been 29,603 publications on this subject alone. Shorter then goes on to suggest that
‘Does it really matter which diagnoses get into this wretched manual, stuffed as it is with artifacts of every manner?’
With a reach of over 350,000 people, the Scientific American platform enables the author to disseminate his message to a wide audience with the support of an established science journalism brand. However the author, a Professor of history begins by referring to common mental illnesses as artifacts, avoids referencing the scientific literature to support his claims, challenges the choice of diagnostic categories made by the Psychiatric profession for the profession’s diagnostic manual, uses a number of pejorative terms during the course of the article, makes incorrect generalisations about people with certain types of illness, ignores 30 years of progress in an entire scientific discipline, makes repeated errors about diagnostic categories, conflates science and the application of science and then makes inferences about the motives of an entire industry and takes issue with treatment approaches by the Psychiatric profession. The question is why has this article been published under the Scientific American brand?
Bebbington P.E et al. The Camberwell Collaborative Depression Study. I. Depressed probands: Adversity and the form of depression. Br J Psychiatry. 152. 754-65. 1988.
Brown, G.W and Harris, T.O. Social Origins of Depression. Tavistock. London. 1978.
Goodwin F K and Jamison K R. Manic-Depressive Illness. Bipolar Disorders and Recurrent Depression. Oxford University Press. 2007. Chapter 1. p 17.
Jellife, S.E. Some historical phases of the manic-depressive synthesis. Research Publications Association for Research in Nervous and Mental Diseases. 11. 3-47. 1931.
Rush B. Medical Inquiries and Observations upon the Disease of the Mind. Philadelphia:Kimber and Richardson. 1812
* This might be counterintuitive but one way to help think about it is to ask two questions
1. What new knowledge is produced as a result of creating a diagnostic category or refining the diagnostic category?
2. What is the process being used to create a new category or refine an old one and how does this compare with the process of doing scientific research?
An index of the site can be found here. The page contains links to all of the articles in the blog in chronological order. Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail email@example.com. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.