Psychosis and the Immune System News Round-Up June 1st Edition 2013 (Updated 8.6.13)

Mild cognitive impairment was associated with a reduction in quality of life in this study (n=205). The QOL-AD (Alzheimer’s Disease) instrument was used to assess quality of life.

Musical hallucinations were more likely in females and people with left-sided hearing impairment in this study looking at people undergoing audiometry testing. In their sample of 194 people, 3.6% experienced musical hallucinations. Age and severity of hearing impairment were not risk factors however.

In one study (n=131) researchers looked at the relationship between depression and cognition in people with Alzheimer’s Disease. The researchers found that in their study there was no significant change in cognition in cases with remission of Depression at 24 weeks.

The relationship between Depressive symptoms in women over the age of 85 was examined in this study (n=302). Researchers used the 15 item Geriatric Depression Scale and found that with a score of <6 at baseline 46% had normal cognitive status 5 years later. With a score >6 at baseline 19% had normal cognitive status 5 years later.

In a small fMRI study researchers looked at 15 people with late life depression and 13 controls . Previous research would suggest decreased executive performance in people with Depression. In this study the researchers found that on a test of executive performance there was increased activation in various parts of the Brain in people with late life Depression compared with controls. The study showed activation was increased in areas including the Superior Frontal cortex bilaterally, Insular cortex, Caudate and Putamen.

Professor Julian Leff has been using virtual reality environments to help people with Schizophrenia who hear voices, manage their experiences. There is a write-up here.

Dr Emily Dean has an interesting piece on NMDA receptor antibody encephalitis as a cause of Schizophrenia with papers presented at the recent American Psychiatric Association annual meeting.

There is a write-up of a study by older adult psychiatrist Dr Tony Rao here in which he found that over the 10 year study period admissions for older adults with alcohol misuse had increased 150%.

In one study researchers looked at 581 people undergoing major non-cardiac surgery. They identified a number of risk factors for developing Delirium and stratified people into low and high risk groups. For the entire group the risk of  postoperative delirum was 40% at 1-2 days post-op. The high risk group developed Delirium in 72% of cases if they had postoperative pain and used high dose Opioids. In comparison those in the low risk group who used low-dose Opioids and low level pain developed Delirium in 20% of cases. As Delirium is common, these findings are helpful in monitoring emerging Delirium.

There is a write-up here of a study looking at bright light therapy for daytime sleepiness in 18 people with traumatic brain injury.


There is a study in rats that suggests that forgetting is more difficult in older rats. These findings might be relevant for humans.


Dr Raj Persaud and Professor Simon Wessely are hosting a conference on the subject of DSM-5 in London (see here and here).


News Round-Up 2008-2011

News Round-Up 2012

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

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