In building a model of the Insular Cortex in emotions it is necessary to first look at the function of other brain regions thought to be involved in emotions. The Fornix is part of the Limbic System, receiving input from the Hippocampus. The Fornix has been suggested to have a role in fear and romantic love.
There is a very good review by Thomas and colleagues which looks at the anatomy in health and disease. They comment on the consequences of damage to the Fornix. This pattern mirrors the impairments that result from involvement of other structures including the mamillary bodies in Korsakoff’s Syndrome (this is a syndrome which is associated with persistent excessive alcohol intake but also with insufficient dietary Thiamine intake).
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