Two features of Dementia in Alzheimer’s Disease are basal forebrain atrophy and a build up of Amyloid plaque. Neuropathology studies have found a link between the two. Now a recent study (n=225) used a combination of PET and structural MRI to investigate this relationship. The results in this study again supported this relationship.
Researchers in this study (n=138) used biomarker data from the Alzheimer’s Disease Neuroimaging Initiative to investigate amnestic Mild Cognitive Impairment (MCI). The researchers were able to stratify people with amnestic MCI.
Biomarkers for Dementia in Alzheimer’s Disease (DAT) were investigated in this study. Researchers followed up 340 people over 10 years. They found medial Temporal lobe atrophy was associated with incipient DAT up to 5 years in advance. They also found that Tempoparietal Cortex involvement was associated with the preclinical phase of DAT.
The Framingham Heart study is a long term study looking at cardiovascular health. A recent analysis of the data was published. The researchers found 777 cases of incipient Dementia in 7901 people. Researchers found that the lifetime risk at age 45 was
1:5 for women
1:10 for men
The researchers also found that cardiovascular mortality in adult men decreased with age. Essentially these findings suggest that men surviving into older adulthood in the study have better cardiovascular health than men at a younger age in the study. As cardiovascular health is linked to Dementia risk this may explain the difference in findings in men and women.
New Scientist have an interesting article on musical hallucinations.
John Hawks has an interesting article on self-medication in H.Neanderthalensis.
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