Two features of Dementia in Alzheimer’s Disease are basal forebrain atrophy and a build up of Amyloid plaque. Neuropathology studies have found a link between the two. Now a recent study (n=225) used a combination of PET and structural MRI to investigate this relationship. The results in this study again supported this relationship.
Researchers in this study (n=138) used biomarker data from the Alzheimer’s Disease Neuroimaging Initiative to investigate amnestic Mild Cognitive Impairment (MCI). The researchers were able to stratify people with amnestic MCI.
Biomarkers for Dementia in Alzheimer’s Disease (DAT) were investigated in this study. Researchers followed up 340 people over 10 years. They found medial Temporal lobe atrophy was associated with incipient DAT up to 5 years in advance. They also found that Tempoparietal Cortex involvement was associated with the preclinical phase of DAT.
The Framingham Heart study is a long term study looking at cardiovascular health. A recent analysis of the data was published. The researchers found 777 cases of incipient Dementia in 7901 people. Researchers found that the lifetime risk at age 45 was
1:5 for women
1:10 for men
The researchers also found that cardiovascular mortality in adult men decreased with age. Essentially these findings suggest that men surviving into older adulthood in the study have better cardiovascular health than men at a younger age in the study. As cardiovascular health is linked to Dementia risk this may explain the difference in findings in men and women.
New Scientist have an interesting article on musical hallucinations.
John Hawks has an interesting article on self-medication in H.Neanderthalensis.
Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail email@example.com. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog. Conflicts of Interest: For potential conflicts of interest please see the About section.