Daily Archives: January 26, 2017

Alzheimer’s Disease: The Amyloid Hypothesis

CC BY-SA 3.0view terms File:Cerebral amyloid angiopathy -2b- amyloid beta - intermed mag - cropped.jpg Uploaded: 11 December 2010

Micrograph of Amyloid Plaque (see Appendix A for credits)

There is an overview of the Amyloid Hypothesis by Professor John Hardy in this 2009 article. I’ve extracted some features of the Amyloid Hypothesis from this paper and listed them below.

(1) Amyloid is central to all pathophysiological processes that lead to Alzheimer’s Disease

(2) Amyloid (including the ABeta components) is toxic

(3) An increase in Amyloid through increased production, reduced removal or both leads to increased toxicity

(4) Amyloid/ABeta leads to tangle pathophysiology

(5) Tangle pathophysiology leads to neuronal cell death

(6) Reducing Amyloid/A Beta would improve symptoms resulting from the Alzheimer’s Disease process

In the paper, the collection of statements above is referred to as the Amyloid Hypothesis.

Appendix A – Micrograph of Amyloid Plaques Credits

CC BY-SA 3.0. File:Cerebral amyloid angiopathy -2b- amyloid beta – intermed mag – cropped.jpg. Uploaded to Wikimedia: 11 December 2010

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.

 

 

ICD-SNOMED-CT® Harmonisation

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Schulz and colleagues have written a paper on harmonisation between SNOMED-CT and ICD following on from a previous paper. They describe the basis for an ontological framework including a taxonomy, a logical framework and clear definitions for top level classes within the ontology.

There follows a very neat description of statistical classifications and some of the necessary features of ICD which distinguish it from the ontological framework described. While on the surface that sounds problematic, they also justify the necessity of this arrangement in terms of the other functions of ICD.

SNOMED-CT and ICD serve different functions but the authors suggest a solution to harmonisation lies in a multi-layer architecture. This will be a development with profound consequences that may be gradually seen over decades.

Appendix A – Other Posts in the Series on Health Information Exchanges

Arizona Statewide Health Information Exchange

A History of The Health Information Exchange in Pennsylvania

The Arkansas Health Information Exchange – SHARE

The California Health Information Exchange – Cal Index

Creating a Health Information Exchange in Arizona

Health Information Exchanges

Health Information Exchanges and Chronic Conditions

HIPPA and Health Information Exchanges

ICD-11 and SNOMED CT®

Mapping ICD 9 (or 10) to SNOMED CT®

Over 1 Million Relationships: SNOMED CT ®

Standardisation of Health Information Technology in New Zealand

Why Do We Need Electronic Record Systems to Talk to Each Other

Appendix B – Definition of Health Information Exchange

This is the definition of the Health Information Exchange that I use (Hersh et al, 2015)

Health information exchange (HIE), the electronic sharing of clinical information across the boundaries of health care organizations

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.