Alzheimer’s Disease: The Amyloid Hypothesis

CC BY-SA 3.0view terms File:Cerebral amyloid angiopathy -2b- amyloid beta - intermed mag - cropped.jpg Uploaded: 11 December 2010

Micrograph of Amyloid Plaque (see Appendix A for credits)

There is an overview of the Amyloid Hypothesis by Professor John Hardy in this 2009 article. I’ve extracted some features of the Amyloid Hypothesis from this paper and listed them below.

(1) Amyloid is central to all pathophysiological processes that lead to Alzheimer’s Disease

(2) Amyloid (including the ABeta components) is toxic

(3) An increase in Amyloid through increased production, reduced removal or both leads to increased toxicity

(4) Amyloid/ABeta leads to tangle pathophysiology

(5) Tangle pathophysiology leads to neuronal cell death

(6) Reducing Amyloid/A Beta would improve symptoms resulting from the Alzheimer’s Disease process

In the paper, the collection of statements above is referred to as the Amyloid Hypothesis.

Appendix A – Micrograph of Amyloid Plaques Credits

CC BY-SA 3.0. File:Cerebral amyloid angiopathy -2b- amyloid beta – intermed mag – cropped.jpg. Uploaded to Wikimedia: 11 December 2010

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

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Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.




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