Micrograph of Amyloid Plaque (see Appendix A for credits)
There is an overview of the Amyloid Hypothesis by Professor John Hardy in this 2009 article. I’ve extracted some features of the Amyloid Hypothesis from this paper and listed them below.
(1) Amyloid is central to all pathophysiological processes that lead to Alzheimer’s Disease
(2) Amyloid (including the ABeta components) is toxic
(3) An increase in Amyloid through increased production, reduced removal or both leads to increased toxicity
(4) Amyloid/ABeta leads to tangle pathophysiology
(5) Tangle pathophysiology leads to neuronal cell death
(6) Reducing Amyloid/A Beta would improve symptoms resulting from the Alzheimer’s Disease process
In the paper, the collection of statements above is referred to as the Amyloid Hypothesis.
Appendix A – Micrograph of Amyloid Plaques Credits
CC BY-SA 3.0. File:Cerebral amyloid angiopathy -2b- amyloid beta – intermed mag – cropped.jpg. Uploaded to Wikimedia: 11 December 2010
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