Diagram showing Hippocampus, an area affected by Alzheimer’s Disease (credits Appendix A)
In his paper on the Amyloid Cascade Hypothesis, Professor Hardy references two alternative hypotheses which are worth bearing in mind
(a) The Presenilin inhibition hypothesis. The Presenilins genes have been clearly linked to Alzheimer’s Disease and so understanding of the function of their phenotypes (the translation of the gene into molecule product) is important. The Presenilin inhibition hypothesis states that the Presenilins, as subunits of an enzyme are inhibited in their actions. Professor Hardy identifies some critiques of this model.
(b) The Double Hit hypothesis states that as well as changes in the Amyloid Precursor Protein there is a second independent step which leads to changes in the tau protein in late-onset disease. Again Professor Hardy identifies difficulties with this hypothesis.
Appendix A – Credits
Picture by FG Designs. Creative Commons License.
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