Alternatives to the Amyloid Cascade Hypothesis

Stylised Diagram of the Hippocampus - Frank Gaillard

Diagram showing Hippocampus, an area affected by Alzheimer’s Disease (credits Appendix A)

In his paper on the Amyloid Cascade Hypothesis, Professor Hardy references two alternative hypotheses which are worth bearing in mind

(a) The Presenilin inhibition hypothesis. The Presenilins genes have been clearly linked to Alzheimer’s Disease and so understanding of the function of their phenotypes (the translation of the gene into molecule product) is important.  The Presenilin inhibition hypothesis states that the Presenilins, as subunits of an enzyme are inhibited in their actions. Professor Hardy identifies some critiques of this model.

(b) The Double Hit hypothesis states that as well as changes in the Amyloid Precursor Protein there is a second independent step which leads to changes in the tau protein in late-onset disease. Again Professor Hardy identifies difficulties with this hypothesis.

Appendix A – Credits

Picture by FG Designs. Creative Commons License.

Index: There are indices for the TAWOP site here and here

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Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

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