Further Details of the PART Hypothesis

Stylised Diagram of the Hippocampus - Frank Gaillard

Diagram showing Hippocampus, an area affected by Alzheimer’s Disease (credits Appendix A)

Crary and colleagues have written this 2014 paper on PART (Primary Age Related Tauopathy) (see also this paper by Crary). I’ve highlighted a few key points about the hypothesis from this paper

(1) The PART hypothesis is driven by pathological findings

(2) PART distinguishes between pathology and clinical manifestation

(3) Comorbid pathology presents a challenge when identifying ‘pure’ clinical correlates of PART

(4) Ambiguity in the hypothesis. PART has been described as:

(a) Distinct from Alzheimer’s Disease

(b) A subset of Alzheimer’s Disease cases

(c) An early stage of Alzheimer’s Disease (i.e. the Amyloid plaques may be expected to follow the appearance of the tangles)

(d) On a continuum with Alzheimer’s Disease

(5) PART also maps onto the pathology associated with several previous descriptors

(a) ‘Tangle Predominant Senile Dementia’

(b) ‘Tangle only Dementia’

(c) ‘Preferential Development of NFT without senile plaques’

(d) ‘Senile Dementia of the Neurofibrillary Tangle Type’

(6) TPSD (5a above) has previously been classed as a Frontotemporal Lobar Degeneration

The reader can see from the above that there are many possible variations of the hypothesis.

Appendix A – Credits

Picture by FG Designs. Creative Commons License.

Index: There are indices for the TAWOP site here and here

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Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.


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