Diagram showing Hippocampus, an area affected by Alzheimer’s Disease (credits Appendix A)
(1) The PART hypothesis is driven by pathological findings
(2) PART distinguishes between pathology and clinical manifestation
(3) Comorbid pathology presents a challenge when identifying ‘pure’ clinical correlates of PART
(4) Ambiguity in the hypothesis. PART has been described as:
(a) Distinct from Alzheimer’s Disease
(b) A subset of Alzheimer’s Disease cases
(c) An early stage of Alzheimer’s Disease (i.e. the Amyloid plaques may be expected to follow the appearance of the tangles)
(d) On a continuum with Alzheimer’s Disease
(5) PART also maps onto the pathology associated with several previous descriptors
(a) ‘Tangle Predominant Senile Dementia’
(b) ‘Tangle only Dementia’
(c) ‘Preferential Development of NFT without senile plaques’
(d) ‘Senile Dementia of the Neurofibrillary Tangle Type’
(6) TPSD (5a above) has previously been classed as a Frontotemporal Lobar Degeneration
The reader can see from the above that there are many possible variations of the hypothesis.
Appendix A – Credits
Picture by FG Designs. Creative Commons License.
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