Daily Archives: February 1, 2017

ICD-2

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A copy of ICD-2 can be found at the WHO website. This document is 232 pages, features 189 causes of death and is written in French. Dr Jacques Bertillon again headed the team (see reviews of previous classifications below). There is a further reference to the second revision of the international classification of the causes of death in this article at the WHO website. The French Government had arranged the conference for the second revision which was held in 1909.

Appendix A – Other Posts in the Series on Health Information Exchanges

A Literature Review of 40 years of SNOMED

Arizona Statewide Health Information Exchange

A History of The Health Information Exchange in Pennsylvania

The Arkansas Health Information Exchange – SHARE

The California Health Information Exchange – Cal Index

Creating a Health Information Exchange in Arizona

Health Information Exchanges

Health Information Exchanges and Chronic Conditions

HIPPA and Health Information Exchanges

ICD-11 and SNOMED CT®

ICD-SNOMED-CT® Harmonisation

ICD-1 – Well…near enough

Körner Data and SNOMED: A Snapshot from 1988

Mapping ICD 9 (or 10) to SNOMED CT®

Over 1 Million Relationships: SNOMED CT ®

Standardisation of Health Information Technology in New Zealand

Statisticians were Responsible for the Development of an International Classification of Diseases

Why Do We Need Electronic Record Systems to Talk to Each Other

Appendix B – Definition of Health Information Exchange

This is the definition of the Health Information Exchange that I use (Hersh et al, 2015)

Health information exchange (HIE), the electronic sharing of clinical information across the boundaries of health care organizations

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.

 

 

Retromers and the Endosome: Small and Duff’s Dual Pathway Hypothesis

 

800px-hela_cell_endocytic_pathway_labeled_for_egfr_and_transferrin

Electron Micrograph showing Endosomes (E) and Mitochondria (M) – See Appendix A for Credits

In the widely cited Dual Pathway Hypothesis which relates to Alzheimer’s Disease, Small and Duff hypothesised that although both tau and Amyloid were involved in the pathology, it was upstream regulation of both that was important. One of the upstream regulators that they suggested was the Retromer Sorting Pathway. Retromers are proteins that are though to be important in cell recycling and play a role in the Endosomes.

The role of Retromers is far from straightforward and not fully understood. However there is a useful 2012 review by Seaman for the interested reader.

Appendix A – Credits

CC BY 3.0

File:HeLa cell endocytic pathway labeled for EGFR and transferrin.jpg

Created: 1 September 2005 by Matthew R G Russell

 

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.