Video of Saccharomyces Cerevisiae (see Appendix A for Credits)
VPS35 (Vacuolar Protein Sorting Associated Protein 35) is a protein which is part of the Retromer Complex. This protein is specifically referenced in Small and Duff’s Dual Pathway Hypothesis relating to Alzheimer’s Disease.
I undertook a medline search to find out a little more about it. The earliest papers retrieved by the search (the search term was simply VPS35) dated back to 1992 and there were 243 papers in total.
In this paper, Gerhard Paravicini and colleagues look at the function of VPS35 in mutant strains of yeast – Saccharomyces cerevisiae (see the video above). The vacuoles remain similar in appearance to those in the wild type strains. The authors hypothesise that VPS35 is responsible for processing a subset of the proteins in vacuoles.
As an aside, Saccharomyces Cerevisiae are yeast that are used in brewing beers and wines. They have been intensively study in biological research. Whilst we are very different from these yeast, there is a profound benefit from studying genes and proteins in yeast – the sharing of fundamental biological processes across species. When findings are made in Yeast it offers a biological evidence base for a hypothetical model.
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