Video of Saccharomyces Cerevisiae (see Appendix A for Credits)

VPS35 (Vacuolar Protein Sorting Associated Protein 35) is a protein which is part of the Retromer Complex. This protein is specifically referenced in Small and Duff’s Dual Pathway Hypothesis relating to Alzheimer’s Disease.

I undertook a medline search to find out a little more about it. The earliest papers retrieved by the search (the search term was simply VPS35) dated back to 1992 and there were 243 papers in total.

In this paper, Gerhard Paravicini and colleagues look at the function of VPS35 in mutant strains of yeast – Saccharomyces cerevisiae (see the video above). The vacuoles remain similar in appearance to those in the wild type strains. The authors hypothesise that VPS35 is responsible for processing a subset of the proteins in vacuoles.

As an aside, Saccharomyces Cerevisiae are yeast that are used in brewing beers and wines. They have been intensively study in biological research. Whilst we are very different from these yeast, there is a profound benefit from studying genes and proteins in yeast – the sharing of fundamental biological processes across species. When findings are made in Yeast it offers a biological evidence base for a hypothetical model.

Appendix A

The video is from Dr Alan Cann’s video channel and the MicrobiologyBytes Video Library: http://microbiologybytes.com/video

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.





Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s