VPS35 in Parkinson’s Disease

DNA code analysis

In previous posts, we have looked at Small and Duff’s Dual Pathway hypothesis relating to Alzheimer’s Disease. This specifically mentions VPS35 as a potential upstream regulator of Amyloid and Tau pathology.

In the literature VPS35 is frequently discussed in relation to Parkinson’s Disease. In this paper by Gambardella and colleagues, they look at the relationship between Vacuolar Protein Sorting Genes and Parkinson’s Disease.

In their review of the literature they note that

(a) p.Asp620Asn is the most common mutation in VPS35 in Parksinson’s Disease

(b) There are a number of other rarer mutations

(c) The prevalence of VPs35 mutations in PD* reaches 0.22%

(d) Quoting a study by Tang et al, they note that modelling the biological correlates of the clinical findings (i.e. mutations) is not so straightforward and much remains to be clarified.

The authors also cover other components of the Retromer complex and also evidence for the possible pathophysiology involved.

*They refer to mixed PD which I interpreted as the combination of Familial and Sporadic cases

Index: There are indices for the TAWOP site here and here

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Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.







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