Daily Archives: February 15, 2017

Glycogenesis, GSK and Alzheimer’s Disease

glycogenesis

Glycogenesis by Mark Cicade (CC-BY-SA-4.0)

The above diagram illustrates the process leading to the synthesis of Glycogen from Glucose in the body. Glycogen essentially acts as the body’s store of Glucose for later use as necessary.

One of the key enzymes in this process is Glycogen Synthase. This enzyme is inactivated by another enzyme called Glycogen Synthase Kinase 3 or GSK 3 for short.

GSK-3 is one of the upstream regulators of Amyloid and Tau pathology in Small and Duffy’s Dual Pathway Hypothesis of Alzheimer’s Disease.

Index: There are indices for the TAWOP site here and here

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Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.

The Insular Cortex and SNOMED CT®

Model Brain

We looked at the SNOMED CT® international browser in this post and the utilisation of the Brodmann Areas in this post. I noted that some of the Brodmann Areas were omitted from the SNOMED CT classification.

So what about the Insular Cortex. There are two ways that this is classified in the SNOMED CT® terminology. I have written previously about the Brodmann Areas in relation to the Insular Cortex. The Insular Cortex is described in several Brodmann Areas – 13, 14 and 52. Interestingly BA 13 and 14 are not included in the SNOMED CT® terminology.

In the previous posts, I noted that Brodmann’s description of BA 13 is only in the Guenon monkey.

There is a second descriptor used in SNOMED CT® for brain structures and this includes the different parts of the Insular Cortex and is represented by 9 digit descriptors.

Appendix A – Other Posts in the Series on Health Information Exchanges

A Literature Review of 40 years of SNOMED

Arizona Statewide Health Information Exchange

A History of The Health Information Exchange in Pennsylvania

The Arkansas Health Information Exchange – SHARE

The California Health Information Exchange – Cal Index

Creating a Health Information Exchange in Arizona

Health Information Exchanges

Health Information Exchanges and Chronic Conditions

HIPPA and Health Information Exchanges

ICD-11 and SNOMED CT®

ICD-SNOMED-CT® Harmonisation

ICD-1 – Well…near enough

ICD-2

ICD-3

ICD-4

ICD-5

ICD-6

ICD-7

ICD-8

ICD-9

ICD-10

ICD-11

Körner Data and SNOMED: A Snapshot from 1988

Mapping ICD 9 (or 10) to SNOMED CT®

Over 1 Million Relationships: SNOMED CT ®

SNOMED CT® International Browser

SNOMED CT® Utilises the Brodmann Area Classification for Brain Regions

What’s a Kinkajou got to do with 21st Century Medical Terminology?

Standardisation of Health Information Technology in New Zealand

Statisticians were Responsible for the Development of an International Classification of Diseases

Why Do We Need Electronic Record Systems to Talk to Each Other

Appendix B – Definition of Health Information Exchange

This is the definition of the Health Information Exchange that I use (Hersh et al, 2015)

Health information exchange (HIE), the electronic sharing of clinical information across the boundaries of health care organizations

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.