Lithium – Photograph by W.Oelen (CC BY S.A 3.0)
We looked at Glycogen Synthase Kinase 3 in previous posts. This enzyme has been referenced in Small and Duffy’s Dual Pathway hypothesis of Alzheimer’s Disease.
Beurel and colleagues review the regulation and actions of GSK 3 as well as diseases that have been linked to GSK 3 in this paper.
The authors identify two key findings that have led to GSK being a focus for research
- The involvement of GSK 3 in Tau phosphorylation – a process which has been implicated in Alzheimer’s Disease.
- GSK 3 is a key target for Lithium.
The story is a lot more complex than this however as GSK is involved in many different pathways.
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