APOE and Aging

DNA code analysis
In previous posts we looked at a review by Dose J, Huebbe P, Nebel A and Rimbach G titled  ‘APOE4 genotype and stress response – a mini review’. APOE4 is referenced as an upstream regulator of Tau and Amyloid pathology in Small and Duff’s Dual Pathway Hypothesis.
In their paper, Dose and colleagues note several lines of evidence from murine studies  suggesting that APOE plays a role in the aging process. When the APOE gene is inactive this results (amongst other findings) in
(1) An increase in atherosclerosis
(2) Increased oxidative stress
(3) Loss of hair follicles
(4) Shortened lifespan


Dose J, Huebbe P, Nebel A, Rimbach G. APOE genotype and stress response – a mini review. Lipids in Health and Disease. 2016;15:121. doi:10.1186/s12944-016-0288-2.

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Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.

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