In previous posts we looked at a review by Dose J, Huebbe P, Nebel A and Rimbach G titled ‘APOE4 genotype and stress response – a mini review’. Dose and colleagues noted evidence that APOE4 binds to mitochondrial complexes III and IV.
(d) Rapid progression of the neurological manifestations
(d) Mitochondrial complex III deficiency does not play a significant role in the pathological effects of APOE4
From my perspective the paper above is more suggestive of a subcortical than cortical pathology.
Dose J, Huebbe P, Nebel A, Rimbach G. APOE genotype and stress response – a mini review. Lipids in Health and Disease. 2016;15:121. doi:10.1186/s12944-016-0288-2.
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