There are various hypotheses to explain the aetiology of Alzheimer’s Disease which is a common cause of Dementia. One key hypothesis focuses on brain metabolism. For the sake of convenience I have labelled this hypothesis the ‘Brain Hypometabolism Hypothesis’ (BHH).
The BHH hypothesis stated simply is that:
Brain hypometabolism leads to neuropathology.
This statement references many pathophysiological pathways and lines of evidence from different research teams in studies spanning several decades.
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