The Brain Hypometabolism Hypothesis: Part 7: Does Atrophy Lead to Hypometabolism?


In their 2016 paper Cunnane and colleagues ask the question

Does atrophy in a brain region account for brain hypometabolism?

They also answer this question by referencing risk factors for Alzheimer’s Type Dementia where brain glucose hypometabolism occurs even in the absence of cognitive impairment

  • Pre-senilin-1 mutation,
  • Apolipoprotein E4 carrier status
  • Matrilinear AD
  • Cognitively healthy aging
  • Insulin resistance

There are five lines of evidence for further investigation of the question above. However the relationship cited above looks at cognitive impairment. Cognitive impairment is a proxy marker. The key question is whether there is brain atrophy which is causing the brain hypometabolism.

So the question can be asked for each of the five risk factors identified above.

The Brain Hypometabolism Hypothesis: Summary of Posts To Date

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

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Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section

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