In their 2016 paper Cunnane and colleagues ask the question
Does atrophy in a brain region account for brain hypometabolism?
They also answer this question by referencing risk factors for Alzheimer’s Type Dementia where brain glucose hypometabolism occurs even in the absence of cognitive impairment
- Pre-senilin-1 mutation,
- Apolipoprotein E4 carrier status
- Matrilinear AD
- Cognitively healthy aging
- Insulin resistance
There are five lines of evidence for further investigation of the question above. However the relationship cited above looks at cognitive impairment. Cognitive impairment is a proxy marker. The key question is whether there is brain atrophy which is causing the brain hypometabolism.
So the question can be asked for each of the five risk factors identified above.
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