The Brain Hypometabolism Hypothesis Part 13: Meta-analysis of Diabetes and Risk of Dementia

Demographic Chart

Gudala and colleagues published a meta-analysis of prospective observational studies in 2013 looking at the relationship between Diabetes and the risk of Dementia. The researchers screened 67,083 papers and identified 28 papers for inclusion. The papers included are found in Table 1 and include the Rotterdam study.

The meta-analysis included 1,148,041 patients and of these 89,708 had a diagnosis of Diabetes (although I couldn’t see a distinction between NIDDM and IDDM).

In people with Diabetes the relative risk of Dementia was:-

(1) Alzheimer’s Type Dementia: Pooled RR 1.56 (95% CI 1.41–1.73)

(2) Vascular Dementia: Pooled RR 2.27 (95% CI 1.94–2.66)

The researchers suggested several mechanisms that may lead to the increased risk including advanced glycation end-products.


Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies. Journal of Diabetes Investigation. 2013;4(6):640-650. doi:10.1111/jdi.12087.

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Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

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