The Brain Hypometabolism Hypothesis Part 13: Meta-analysis of Diabetes and Risk of Dementia

Demographic Chart

Gudala and colleagues published a meta-analysis of prospective observational studies in 2013 looking at the relationship between Diabetes and the risk of Dementia. The researchers screened 67,083 papers and identified 28 papers for inclusion. The papers included are found in Table 1 and include the Rotterdam study.

The meta-analysis included 1,148,041 patients and of these 89,708 had a diagnosis of Diabetes (although I couldn’t see a distinction between NIDDM and IDDM).

In people with Diabetes the relative risk of Dementia was:-

(1) Alzheimer’s Type Dementia: Pooled RR 1.56 (95% CI 1.41–1.73)

(2) Vascular Dementia: Pooled RR 2.27 (95% CI 1.94–2.66)

The researchers suggested several mechanisms that may lead to the increased risk including advanced glycation end-products.

Citation

Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies. Journal of Diabetes Investigation. 2013;4(6):640-650. doi:10.1111/jdi.12087.

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section

 

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s