In her 2014 paper, Dr de la Monte discusses the concept of Type 3 Diabetes which I refer to here as the Type 3 Diabetes Model (T3DM). The key molecules in the T3DM are Insulin and Insulin-like Growth Factors. In the paper Dr de la Monte outlines the various important functions that Insulin has in the brain ranging from anti-apoptosis through to growth, plasticity and metabolism. Although the model is more nuanced I will summarise this as
‘Insulin and Insulin-like Growth Factor Dysfunction Leads to Neuropathology‘
The dysfunction results from the secretion and activity of the Insulin and IGF’s as well as resistance to their action.
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