The Brain Hypometabolism Hypothesis Part 15: The Role of Insulin and Insulin Like Growth Factors in the T3DM


In her 2014 paper, Dr de la Monte discusses the concept of Type 3 Diabetes which I refer to here as the Type 3 Diabetes Model (T3DM). The key molecules in the T3DM are Insulin and Insulin-like Growth Factors. In the paper Dr de la Monte outlines the various important functions that Insulin has in the brain ranging from anti-apoptosis through to growth, plasticity and metabolism. Although the model is more nuanced I will summarise this as

Insulin and Insulin-like Growth Factor Dysfunction Leads to Neuropathology

The dysfunction results from the secretion and activity of the Insulin and IGF’s as well as resistance to their action.

Index: There are indices for the TAWOP site here and here

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Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.






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