The Brain Hypometabolism Hypothesis Part 23: GLUT1


Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century‘. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.

Addressing GLUT1, Thorens and Mueckler refer to this as the most intensively studied of this family.

GLUT1 is expressed in the endothelial cells that constitute the blood brain barrier. There is an emerging discussion about how GLUT1 specifically might be involved in neurodegenerative conditions such as Alzheimer’s Type Dementia (e.g. see this paper).

Appendix A – Citations

Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

Barros LF, San Martín A, Ruminot I, Sandoval PY, Fernández-Moncada I Baeza-Lehnert F, Arce-Molina R, Contreras-Baeza Y, Cortés-Molina F, Galaz A, Alegría K.J Neurosci Res. 2017 Feb 2. doi: 10.1002/jnr.23998. [Epub ahead of print]Near-critical GLUT1 and Neurodegeneration.

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