The Brain Hypometabolism Hypothesis Part 29: GLUT 7

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Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century‘. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.

In their paper, Thorens and Mueckler note that there is little data on GLUT 7 other than to say it is similar in structure to GLUT 5 and is not very effective for either Glucose or Fructose as a transporter. Therefore Thorens and Mueckler suggest it is effective for another substrate. The suggestion of another substrate is reiterated in this paper.

 

Appendix A – Citations

Ebert K, Ludwig M, Geillinger KE, Schoberth GC, Essenwanger J, Stolz J, Daniel H, Witt H.Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters.
J Membr Biol. 2017 Jan 12. doi: 10.1007/s00232-016-9945-7. [Epub ahead of print]

Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

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