Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century‘. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.
In their paper, Thorens and Mueckler note that there is little data on GLUT 7 other than to say it is similar in structure to GLUT 5 and is not very effective for either Glucose or Fructose as a transporter. Therefore Thorens and Mueckler suggest it is effective for another substrate. The suggestion of another substrate is reiterated in this paper.
Appendix A – Citations
Ebert K, Ludwig M, Geillinger KE, Schoberth GC, Essenwanger J, Stolz J, Daniel H, Witt H.Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters.
J Membr Biol. 2017 Jan 12. doi: 10.1007/s00232-016-9945-7. [Epub ahead of print]
Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.
TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.
Responses: If you have any comments, you can leave them below or alternatively e-mail email@example.com.
Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.
Conflicts of Interest: *For potential conflicts of interest please see the About section