The Brain Hypometabolism Hypothesis Part 30: GLUT 8


Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century’. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.

In their paper, Thorens and Mueckler note that GLUT8 has been linked to neuronal proliferation in the Hippocampus. This paper implicates GLUT8 in both Hippocampal neuroproliferation and also an increase in the atrial p-wave duration.

Appendix A – Citations

Membrez M, Hummler E, Beermann F, et al. GLUT8 Is Dispensable for Embryonic Development but Influences Hippocampal Neurogenesis and Heart Function. Molecular and Cellular Biology. 2006;26(11):4268-4276. doi:10.1128/MCB.00081-06.
Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

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