Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century’. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.
Thorens and Mueckler note in their 2009 paper that not much is known about GLUT 11 other than an affinity for both Glucose and Fructose. A 2017 medline search using the search term “GLUT11” retrieved only 14 results and for “SLC2A11” also. Few of these papers post-dated the 2009 review and there was little discussion about the brain. This does not discount the possibility of a significant role in brain metabolism but it looks as though this is not an area of active research.
Appendix A – Citations
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