Daily Archives: April 5, 2017

The Brain Hypometabolism Hypothesis Part 34: GLUT 12

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Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century’. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.

This paper suggests properties of the GLUT12 transporter that differ from other members of the GLUT family and hint at an as yet undiscovered substrate. The authors note that previously it has been proposed as an ancestor of GLUT4 with ancillary function. They identify complex aspects of its action and also transport to the plasma membrane. They suggest that GLUT12 is involved in Glucose homeostasis throughout the body.

Appendix A – Citations

Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

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The NHS Number

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There is an NHS interoperability handbook here. Appendix A features a table which maps current standards to the interoperability framework layers. One of the standards that map onto the interoperability framework is the NHS number.

There is more information on the NHS number on this archived National Information Board webpage. The NHS number is 10 digits with the last digit being used as a check which enables the use of algorithms in healthcare software to check the integrity of NHS numbers in the database.

General Posts to Date on Health Information Exchanges

Posts on Examples of Health Information Exchanges

SNOMED CT®/ICD Mapping and Harmonisation Posts

SNOMED CT® Posts

ICD 1-10 Posts

ICD-11 Posts

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section