The Brain Hypometabolism Hypothesis Part 34: GLUT 12

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Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century’. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.

This paper suggests properties of the GLUT12 transporter that differ from other members of the GLUT family and hint at an as yet undiscovered substrate. The authors note that previously it has been proposed as an ancestor of GLUT4 with ancillary function. They identify complex aspects of its action and also transport to the plasma membrane. They suggest that GLUT12 is involved in Glucose homeostasis throughout the body.

Appendix A – Citations

Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

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