Category Archives: psychiatry

Questions Raised by the Model: Building a Model of the Insular Cortex – Part 21

A Model of the Insular Cortex

In the last post we looked at some of the features of the model as it begins to take shape. Could the Insular Cortex act as a transformer in a simple system where physiological responses are translated into emotional experiences in a single part of the brain.

Such a model as it is stated is simple, perhaps too simple and raises a number of questions

1. Does information from physiological responses require more than one step to be transformed into emotional experiences?

2. If a transformative function is required should this occur in just a single location or like many functions would this be distributed?

3. If the Insular Cortex were the only location for this transformation then would that determine many of the anatomical relationships it has with other structures e.g. would it need a direct or indirect connection with all other areas involved in emotional experience or regulation?

4. What constitutes a physiological response? The perception of neutral stimuli in the environment is a physiological response involving the sensory and perceptual apparatus. Do the physiological responses relevant to this discussion have to be characterised?

Related Resources on this Site

Developing a Model of the Insular Cortex and Emotional Regulation: Part 1

Building a Model of the Insular Cortex – Part 2: Reviewing a Model by Craig – Part 1

Building a Model of the Insular Cortex – Part 3: Reviewing a Model by Craig – Part 2

Building a Model of the Insular Cortex – Part 4: Reviewing a Model by Craig – Part 3

Building a Model of the Insular Cortex – Part 5: The Evolution of the Insular Cortex

Building a Model of the Insular Cortex – Part 6: A Recap

Building a Model of the Insular Cortex – Part 7: The James-Lange Theory

Building a Model of the Insular Cortex – Part 8: The Cannon-Bard Thalamic Theory of Emotions

Building a Model of the Insular Cortex – Part 9: Charles Darwin on the Expression of the Emotions

Building a Model of the Insular Cortex – Part 10: The Limbic System

Building a Model of the Insular Cortex – Part 11: A Second Recap

Building a Model of the Insular Cortex – Part 12: GABA receptors and Emotions

Building a Model of the Insular Cortex – Part 13: GABA receptors and Nematode Worms

Building a Model of the Insular Cortex – Part 14: Are GABA Receptors Related to Anxiety in Humans Because Worms Wriggle?

Building a Model of the Insular Cortex – Part 15: Another Recap

A Diversion into the Limbic System: Building a Model of the Insular Cortex – Part 16

A Look at the Amygdala-PFC Dyad – Building a Model of the Insular Cortex – Part 17

What does the Insular Cortex Do Again?

Insular Cortex Infarction in Acute Middle Cerebral Artery Territory Stroke

The Insular Cortex and Neuropsychiatric Disorders

The Relationship of Blood Pressure to Subcortical Lesions

Pathobiology of Visceral Pain

Interoception and the Insular Cortex

A Case of Neurogenic T-Wave Inversion

Video Presentations on a Model of the Insular Cortex

MR Visualisations of the Insula

The Subjective Experience of Pain

How Do You Feel? Interoception: The Sense of the Physiological Condition of the Body

How Do You Feel – Now? The Anterior Insula and Human Awareness

Role of the Insular Cortex in the Modulation of Pain

The Insular Cortex and Frontotemporal Dementia

A Case of Infarct Connecting the Insular Cortex and the Heart

The Insular Cortex: Part of the Brain that Connects Smell and Taste?

Stuttered Swallowing and the Insular Cortex

YouTubing the Insular Cortex (Brodmann Areas 13, 14 and 52)

New Version of Video on Insular Cortex Uploaded

Contributors to the Model (links are to the posts in which contributions were made – these links may contain further links directly to the contributors)

Ann Nonimous

The Neurocritic

Psico-logica

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Building a Model of the Insular Cortex – Part 20

A Model of the Insular Cortex

In preceding posts we have looked at various models of emotions in the brain which have allowed the contextualisation of a model of the Insular Cortex. Two early and general models of emotions look at the relationship between emotions and physiological responses to stimuli.

There are at least two ways in which this relationship can happen. We sense a stimulus – a spider for example. When we see the spider we experience fear and our heart starts to race. Or else we see the spider and our heart races and we respond with the sense of fear.

In this simplistic model there would need to be a means of transforming information from physiological responses into emotional experiences. In this context we can start with the hypothesis that the Insular Cortex is a transformer. In just the same way we could also argue that the Insular Cortex transmits information from physiological responses or else that it is the location for emotional experiences.

Regardless of whether this is correct or not, this explicit hypothesis enables us to explore the function of the Insular Cortex and also the question of whether information from physiological responses can be converted directly into emotional experiences or whether one or more transformative steps are required.

There are still a few steps before the contextualised model can be stated.

Related Resources on this Site

Developing a Model of the Insular Cortex and Emotional Regulation: Part 1

Building a Model of the Insular Cortex – Part 2: Reviewing a Model by Craig – Part 1

Building a Model of the Insular Cortex – Part 3: Reviewing a Model by Craig – Part 2

Building a Model of the Insular Cortex – Part 4: Reviewing a Model by Craig – Part 3

Building a Model of the Insular Cortex – Part 5: The Evolution of the Insular Cortex

Building a Model of the Insular Cortex – Part 6: A Recap

Building a Model of the Insular Cortex – Part 7: The James-Lange Theory

Building a Model of the Insular Cortex – Part 8: The Cannon-Bard Thalamic Theory of Emotions

Building a Model of the Insular Cortex – Part 9: Charles Darwin on the Expression of the Emotions

Building a Model of the Insular Cortex – Part 10: The Limbic System

Building a Model of the Insular Cortex – Part 11: A Second Recap

Building a Model of the Insular Cortex – Part 12: GABA receptors and Emotions

Building a Model of the Insular Cortex – Part 13: GABA receptors and Nematode Worms

Building a Model of the Insular Cortex – Part 14: Are GABA Receptors Related to Anxiety in Humans Because Worms Wriggle?

Building a Model of the Insular Cortex – Part 15: Another Recap

A Diversion into the Limbic System: Building a Model of the Insular Cortex – Part 16

A Look at the Amygdala-PFC Dyad – Building a Model of the Insular Cortex – Part 17

Building a Model of the Insular Cortex – Part 19

What does the Insular Cortex Do Again?

Insular Cortex Infarction in Acute Middle Cerebral Artery Territory Stroke

The Insular Cortex and Neuropsychiatric Disorders

The Relationship of Blood Pressure to Subcortical Lesions

Pathobiology of Visceral Pain

Interoception and the Insular Cortex

A Case of Neurogenic T-Wave Inversion

Video Presentations on a Model of the Insular Cortex

MR Visualisations of the Insula

The Subjective Experience of Pain

How Do You Feel? Interoception: The Sense of the Physiological Condition of the Body

How Do You Feel – Now? The Anterior Insula and Human Awareness

Role of the Insular Cortex in the Modulation of Pain

The Insular Cortex and Frontotemporal Dementia

A Case of Infarct Connecting the Insular Cortex and the Heart

The Insular Cortex: Part of the Brain that Connects Smell and Taste?

Stuttered Swallowing and the Insular Cortex

YouTubing the Insular Cortex (Brodmann Areas 13, 14 and 52)

New Version of Video on Insular Cortex Uploaded

Contributors to the Model (links are to the posts in which contributions were made – these links may contain further links directly to the contributors)

Ann Nonimous

The Neurocritic

Psico-logica

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Returning to the Beginning: Building a Model of the Insular Cortex – Part 19

A Model of the Insular Cortex

Almost 5 years ago, we looked at a model of the Insular Cortex that started with a few assumptions from some papers which included one looking at GABA receptors in the Insular Cortex and anxiety. Along the way we looked at works by Antonio Damasio and A.Bud.Craig. More recently we have looked at other areas of the brain implicated in our emotional experiences as well as some of the influential models of the Limbic System.

Returning to the beginning and looking at how to build such a model it seems sensible to contextualise the model in terms of the most influential theories in this area. William James and Carl Lange raised the question of whether we first experience physiological reactions and then emotions whilst in the Cannon-Bard theory the reverse is stated. In either case there is a stated connection between physiological reactions to events and emotions.

These physiological reactions in the body produce information. The process of responding to this information is interoception. The Insular Cortex receives interoceptive input from the body leading to a posited role in interoception. Referring to the discussion above we can see that the Insular Cortex is therefore a natural point of enquiry for exploring the relationship between physiological responses to events and our emotional experiences.

Related Resources on this Site

Developing a Model of the Insular Cortex and Emotional Regulation: Part 1

Building a Model of the Insular Cortex – Part 2: Reviewing a Model by Craig – Part 1

Building a Model of the Insular Cortex – Part 3: Reviewing a Model by Craig – Part 2

Building a Model of the Insular Cortex – Part 4: Reviewing a Model by Craig – Part 3

Building a Model of the Insular Cortex – Part 5: The Evolution of the Insular Cortex

Building a Model of the Insular Cortex – Part 6: A Recap

Building a Model of the Insular Cortex – Part 7: The James-Lange Theory

Building a Model of the Insular Cortex – Part 8: The Cannon-Bard Thalamic Theory of Emotions

Building a Model of the Insular Cortex – Part 9: Charles Darwin on the Expression of the Emotions

Building a Model of the Insular Cortex – Part 10: The Limbic System

Building a Model of the Insular Cortex – Part 11: A Second Recap

Building a Model of the Insular Cortex – Part 12: GABA receptors and Emotions

Building a Model of the Insular Cortex – Part 13: GABA receptors and Nematode Worms

Building a Model of the Insular Cortex – Part 14: Are GABA Receptors Related to Anxiety in Humans Because Worms Wriggle?

Building a Model of the Insular Cortex – Part 15: Another Recap

A Diversion into the Limbic System: Building a Model of the Insular Cortex – Part 16

A Look at the Amygdala-PFC Dyad – Building a Model of the Insular Cortex – Part 17

What does the Insular Cortex Do Again?

Insular Cortex Infarction in Acute Middle Cerebral Artery Territory Stroke

The Insular Cortex and Neuropsychiatric Disorders

The Relationship of Blood Pressure to Subcortical Lesions

Pathobiology of Visceral Pain

Interoception and the Insular Cortex

A Case of Neurogenic T-Wave Inversion

Video Presentations on a Model of the Insular Cortex

MR Visualisations of the Insula

The Subjective Experience of Pain

How Do You Feel? Interoception: The Sense of the Physiological Condition of the Body

How Do You Feel – Now? The Anterior Insula and Human Awareness

Role of the Insular Cortex in the Modulation of Pain

The Insular Cortex and Frontotemporal Dementia

A Case of Infarct Connecting the Insular Cortex and the Heart

The Insular Cortex: Part of the Brain that Connects Smell and Taste?

Stuttered Swallowing and the Insular Cortex

YouTubing the Insular Cortex (Brodmann Areas 13, 14 and 52)

New Version of Video on Insular Cortex Uploaded

Contributors to the Model (links are to the posts in which contributions were made – these links may contain further links directly to the contributors)

Ann Nonimous

The Neurocritic

Psico-logica

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Fear and Love in the Brain – A Look at the Fornix: Building a Model of the Insular Cortex – Part 18 (Updated 27.8.13)

A Model of the Insular Cortex

In building a model of the Insular Cortex in emotions it is necessary to first look at the function of other brain regions thought to be involved in emotions. The Fornix is part of the Limbic System, receiving input from the Hippocampus. The Fornix has been suggested to have a role in fear and romantic love.

Fornix

There is a very good review by Thomas and colleagues which looks at the anatomy in health and disease. They comment on the consequences of damage to the Fornix. This pattern mirrors the impairments that result from involvement of other structures including the mamillary bodies in Korsakoff’s Syndrome (this is a syndrome which is associated with persistent excessive alcohol intake but also with insufficient dietary Thiamine intake).

There is a body of literature suggesting that the Fornix is involved in the fear response according to the context and that this fear response is dependent on the theta rhythm in the Hippocampus.

Related Resources on this Site

Developing a Model of the Insular Cortex and Emotional Regulation: Part 1

Building a Model of the Insular Cortex – Part 2: Reviewing a Model by Craig – Part 1

Building a Model of the Insular Cortex – Part 3: Reviewing a Model by Craig – Part 2

Building a Model of the Insular Cortex – Part 4: Reviewing a Model by Craig – Part 3

Building a Model of the Insular Cortex – Part 5: The Evolution of the Insular Cortex

Building a Model of the Insular Cortex – Part 6: A Recap

Building a Model of the Insular Cortex – Part 7: The James-Lange Theory

Building a Model of the Insular Cortex – Part 8: The Cannon-Bard Thalamic Theory of Emotions

Building a Model of the Insular Cortex – Part 9: Charles Darwin on the Expression of the Emotions

Building a Model of the Insular Cortex – Part 10: The Limbic System

Building a Model of the Insular Cortex – Part 11: A Second Recap

Building a Model of the Insular Cortex – Part 12: GABA receptors and Emotions

Building a Model of the Insular Cortex – Part 13: GABA receptors and Nematode Worms

Building a Model of the Insular Cortex – Part 14: Are GABA Receptors Related to Anxiety in Humans Because Worms Wriggle?

Building a Model of the Insular Cortex – Part 15: Another Recap

A Diversion into the Limbic System: Building a Model of the Insular Cortex – Part 16

A Look at the Amygdala-PFC Dyad – Building a Model of the Insular Cortex – Part 17

What does the Insular Cortex Do Again?

Insular Cortex Infarction in Acute Middle Cerebral Artery Territory Stroke

The Insular Cortex and Neuropsychiatric Disorders

The Relationship of Blood Pressure to Subcortical Lesions

Pathobiology of Visceral Pain

Interoception and the Insular Cortex

A Case of Neurogenic T-Wave Inversion

Video Presentations on a Model of the Insular Cortex

MR Visualisations of the Insula

The Subjective Experience of Pain

How Do You Feel? Interoception: The Sense of the Physiological Condition of the Body

How Do You Feel – Now? The Anterior Insula and Human Awareness

Role of the Insular Cortex in the Modulation of Pain

The Insular Cortex and Frontotemporal Dementia

A Case of Infarct Connecting the Insular Cortex and the Heart

The Insular Cortex: Part of the Brain that Connects Smell and Taste?

Stuttered Swallowing and the Insular Cortex

YouTubing the Insular Cortex (Brodmann Areas 13, 14 and 52)

New Version of Video on Insular Cortex Uploaded

Contributors to the Model (links are to the posts in which contributions were made – these links may contain further links directly to the contributors)

Ann Nonimous

The Neurocritic

Psico-logica

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Refining the Definition of Automatic Speech in the Three Structure Model – Part 4. Integration in Neuroscience: A Core Problem – Part 16

reviseddescriptionofspeechinthreestructuremodel

In previous posts, we’ve looked at Automatic Speech in the three structure model. Just to summarise automatic speech is absolute unconscious activity. The neural activity that results in automatic speech can never result in conscious experience. I wanted to introduce another concept into the discussion – that of choice. In the previous post we looked at fMRI data with superimposed audio showing how speech is produced in real time.

The example was used in a thought experiment to show how each component of speech could at a sufficiently slow rate result from a conscious decision. Therefore in moving forwards my proposal is that automatic speech is that speech beyond conscious control, where the decision to initiate that component of speech is irreversible. By corollary conscious speech components retain an element of reversibility – the final speech output whilst conceived, does not have to take place. Transient conscious activity exists in two forms – with and without choice.

Looking at speech in this way also allows generalisation to upstream parts of the model. Instead of talking about speech we can talk about conscious experience, transient conscious activity and absolute unconscious activity in relation to decision making. If it is valid to use induction then we can say that conscious experience allows the individual to retain choice about actions, transient conscious activity is intermediate – in its essential form choice is removed. However the neural structures underpinning transient conscious activity are capable of manifesting conscious experience and are thereby capable of choice.

Choice/decision making here links in with locus of control and volition/will. The model values the individual actor rather than the elaborate reflexes of behaviourism or the reductionism of biological determinism or some combination thereof. That is not to say that such models are mutually exclusive for it is entirely possible that the intuitive appeal of volition can be expressed in terms of the other models in a way that retains the essence of each.

Appendix – Related Resources on the TAWOP Site

In Support of Method

A Review of the Structure of Scientific Revolutions

An Interpretation of Scientific Revolutions

Integration in Neuroscience: A Core Problem – Part 1

Integration in Neuroscience: A Core Problem – Part 2

Integration in Neuroscience:A Core Problem – Part 3

Integration in Neuroscience: A Core Problem – Part 4: A Language for Mind and Brain?

Integration in Neuroscience: A Core Problem – Part 5: A Three Structure Model

Integration in Neuroscience: A Core Problem – Part 6: Reflection on the Three Structure Model

Integration in Neuroscience: A Core Problem – Part 7: The Unconscious in the Three Structure Model

Integration in Neuroscience: A Core Problem – Part 8

Integration in Neuroscience: A Core Problem – Part 9

Integration in Neuroscience: A Core Problem – Part 10

Integration in Neuroscience: A Core Problem – Part 11

Integration in Neuroscience: A Core Problem – Part 12

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

A Look at the Amygdala: Building a Model of the Insular Cortex – Part 17

A Model of the Insular Cortex

In previous posts we have looked at the Insular Cortex, general models of the emotions and more recently the Hippocampus. The role of the Insular Cortex in emotions must be understood both in terms of the role of the Insular Cortex in other functions (e.g. interoception) as well as the role of other areas in emotions (e.g. the Limbic System). Although an understanding of these related areas is necessary, the understanding does not need to be too sophisticated. We need to come away with some simple assumptions that help to limit and guide the model we are interested in.

There are a number of areas that are thought to be involved in emotions. The Amygdala is one such area and the aim of this post is to look at briefly at what role the Amygdala might play in emotions and how it might do this. The paper used to inform this exploration of the Amgydala is ‘The Structural and Functional Connectivity of the Amygdala: From Normal Emotion to Pathological Anxiety‘ by Kim and colleagues (Kim et al, 2011).

Amgydala

The main points that I took away from this paper are that

1. The medial Prefrontal Cortex (mPFC) and Amygdala are tightly coupled and that the mPFC influences the output of the Amgydala.

2. The Amygdala is connected to many other brain regions. The authors detail the connections with the mPFC noting that diffuse tensor imaging reveals afferent projections to the Amgydala from the caudal and dorsal medial prefrontal cortex.

3. fMRI studies suggest that Amygdala activity is inversely correlated with mPFC activity during tasks involving interpretation of facial expressions.

4. Nuclei in the Amgydala include the basolateral area (BLA) and the centra nucleus (Ce). BLA receives inputs sensory inputs. The central nucleus projects to the Hypothalamus, brainstem nuclei as well as monoaminergic and cholinergic systems.

5. Research studies have shown the Amgydala to be necessary for classical conditioning and extinction.

6. Emotional regulation can be understood in terms of a competition between top-down and bottom-up processes. The Amygdala is central to the resolution of these bidirectional processes. Emotionally ambivalent signals such as fearful faces or surprised faces are interpreted by the Amgydala.

7. The Amygdala-mPFC dyad is involved in suppression or reappraisal of emotional stimuli.

8. The Amygdala-mPFC dyad is involved in pathological anxiety states. Typically there is hypoactivity of the mPFC and hyperactivity of the Amgydala in Amgydala-PFC models of pathological anxiety.

9. In social anxiety disorder there is evidence of involvement of the Amgydala-mPFC circuits including hypoactivation of the mPFC in emotional tasks as well as involvement of the Uncinate fasciculus.

10. One suggestion about Post Traumatic Stress Disorder is that there is an incomplete conditioned fear extinction. There is evidence of reduced mPFC activity in response to frightened faces.

The paper offers an interesting and simple model of the involvement of the Amygdala and medial Prefrontal Cortex in emotional regulation which can be used to contextualise the emotional function of other brain regions.

Related Resources on this Site

Developing a Model of the Insular Cortex and Emotional Regulation: Part 1

Building a Model of the Insular Cortex – Part 2: Reviewing a Model by Craig – Part 1

Building a Model of the Insular Cortex – Part 3: Reviewing a Model by Craig – Part 2

Building a Model of the Insular Cortex – Part 4: Reviewing a Model by Craig – Part 3

Building a Model of the Insular Cortex – Part 5: The Evolution of the Insular Cortex

Building a Model of the Insular Cortex – Part 6: A Recap

Building a Model of the Insular Cortex – Part 7: The James-Lange Theory

Building a Model of the Insular Cortex – Part 8: The Cannon-Bard Thalamic Theory of Emotions

Building a Model of the Insular Cortex – Part 9: Charles Darwin on the Expression of the Emotions

Building a Model of the Insular Cortex – Part 10: The Limbic System

Building a Model of the Insular Cortex – Part 11: A Second Recap

Building a Model of the Insular Cortex – Part 12: GABA receptors and Emotions

Building a Model of the Insular Cortex – Part 13: GABA receptors and Nematode Worms

Building a Model of the Insular Cortex – Part 14: Are GABA Receptors Related to Anxiety in Humans Because Worms Wriggle?

Building a Model of the Insular Cortex – Part 15: Another Recap

A Diversion into the Limbic System: Building a Model of the Insular Cortex – Part 16

What does the Insular Cortex Do Again?

Insular Cortex Infarction in Acute Middle Cerebral Artery Territory Stroke

The Insular Cortex and Neuropsychiatric Disorders

The Relationship of Blood Pressure to Subcortical Lesions

Pathobiology of Visceral Pain

Interoception and the Insular Cortex

A Case of Neurogenic T-Wave Inversion

Video Presentations on a Model of the Insular Cortex

MR Visualisations of the Insula

The Subjective Experience of Pain

How Do You Feel? Interoception: The Sense of the Physiological Condition of the Body

How Do You Feel – Now? The Anterior Insula and Human Awareness

Role of the Insular Cortex in the Modulation of Pain

The Insular Cortex and Frontotemporal Dementia

A Case of Infarct Connecting the Insular Cortex and the Heart

The Insular Cortex: Part of the Brain that Connects Smell and Taste?

Stuttered Swallowing and the Insular Cortex

YouTubing the Insular Cortex (Brodmann Areas 13, 14 and 52)

New Version of Video on Insular Cortex Uploaded

Contributors to the Model (links are to the posts in which contributions were made – these links may contain further links directly to the contributors)

Ann Nonimous

The Neurocritic

Psico-logica

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Automatic Speech in the Three Structure Model – Part 3. Integration in Neuroscience: A Core Problem – Part 15

reviseddescriptionofspeechinthreestructuremodel

In the previous post, we looked more closely at automatic speech with some video examples. Just returning to one of these examples have a look at the clip below.

In the three structure model, automatic speech represents the final common pathway through which speech is actuated. The final common pathway is the electrical activity occurring in the nerves (mostly cranial nerves) that actuate the muscles of speech. It is assumed that this activity is entirely unconscious and is in no way capable of being conscious activity.

If you watch the clip repeatedly and very carefully it becomes clear that unsurprisingly the tongue plays a central role in speech production. Some of the actions that are seen are

1. Mouth opening

2. Lips pursing to articulate sounds

3. Tongue depressing

4. Tongue moving up to touch hard palate

5. Tongue touching soft palate and closing nasopharyngeal air space

If we assemble some of these actions to reproduce the actions at the beginning of the video it would read something like as follows

1. Open Mouth by lowering jaw

2. Depress tongue

3. Push lips together

4. Lift tongue to touch hard palate

5. Move tongue rapidly down

6. Move tongue to soft palate to close off nasopharynx

Whilst this is going on there are two other things happening

1. The force of air expulsion from the lungs is being controlled by the muscles of respiration

2. The vocal cords are being relaxed and contracted whilst the lung air expulsion is vibrating the vocal cords

The combination of all of this results in speech. From the multiple steps above it seems entirely unlikely that conscious or at least potentially conscious activity (i.e. transient unconscious activity) is not playing a central role in the transition from one step to another of this process.

In other words it is highly unlikely that the brain sends a signal to the muscles associated with speech and then sits passively by while all of the actions above take place. It is most likely that the conscious/transient unconscious activity intervenes in each transition.

So for instance you would be able to speak very slowly. In so doing you would exert a clear and conscious control over actions. You could lower your jaw and be absolutely certain that you are consciously in control of this action. You could purse your lips and be similarly confident that you are in conscious control of this action. You could touch the roof of the mouth with your tongue and again be confident that you are in conscious control of this action. By definition such actions are not absolute unconscious activity but conscious/transient conscious activity.

This means that the place for absolute unconscious activity takes a more peripheral role in speech. It becomes much less relevant and probably applies to the last few milliseconds of the signals moving from primary cortex to effector nerves.

If this is correct it would mean that this is recipricocity between streams of conscious speech commands and brief bursts of ‘reflexive’ automatic speech. This much is clear from the above thought experiment but it is also relevant to some of the theoretical knowledge about corticospinal pathways and also their relation to the Cerebellum which is closely involved in the monitoring of motor activities.

Appendix – Related Resources on the TAWOP Site

In Support of Method

A Review of the Structure of Scientific Revolutions

An Interpretation of Scientific Revolutions

Integration in Neuroscience: A Core Problem – Part 1

Integration in Neuroscience: A Core Problem – Part 2

Integration in Neuroscience:A Core Problem – Part 3

Integration in Neuroscience: A Core Problem – Part 4: A Language for Mind and Brain?

Integration in Neuroscience: A Core Problem – Part 5: A Three Structure Model

Integration in Neuroscience: A Core Problem – Part 6: Reflection on the Three Structure Model

Integration in Neuroscience: A Core Problem – Part 7: The Unconscious in the Three Structure Model

Integration in Neuroscience: A Core Problem – Part 8

Integration in Neuroscience: A Core Problem – Part 9

Integration in Neuroscience: A Core Problem – Part 10

Integration in Neuroscience: A Core Problem – Part 11

Integration in Neuroscience: A Core Problem – Part 12

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.