Health Information Exchange 2.0

John Kansky talks about how a well established Health Information Exchange is transforming. The Indiana Health Information Exchange is one of the largest in the USA.

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Index: There are indices for the TAWOP site here and here

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Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section

The Brain Hypometabolism Hypothesis Part 25: GLUT3

glucose_2

Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century‘. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.

In their paper, Thorens and Mueckler note that GLUT 3 is the main glucose transporter in the brain but also plays an important role in embryogenesis.

Appendix A – Citations

Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

Index: There are indices for the TAWOP site here and here

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Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section

 

 

 

 

Challenges for the Maine Health Information Exchange

Devore Culver is the executive director of HealthInfoNet in Maine, USA. In this video he describes some of the challenges facing the establishment of a Health Information Exchange (HIE). There is a particularly interesting discussion about how the HIE interacts witht different healthcare environments. Towards the end of the video he talks about the two forms of financing which are particularly relevant to the US healthcare system and how this impacts on the commissioning.

General Posts to Date on Health Information Exchanges

Posts on Examples of Health Information Exchanges

SNOMED CT®/ICD Mapping and Harmonisation Posts

SNOMED CT® Posts

ICD 1-10 Posts

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Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section

The Brain Hypometabolism Hypothesis Part 24: GLUT2

glucose_2

Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century‘. In their article they note that there are 14 Glucose transporters in humans and that many of their functions are not yet characterised. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.

In the paper they note that there is evidence that GLUT 2 plays a role in glucose ‘sensors’ in the central nervous system and the periphery.

There are a number of papers on GLUT2 and the brain including this one on a possible drug interaction with GLUT2 and this one on Ghrelin and the Hypothalamus.

Appendix A – Citations

Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section

 

 

 

 

The Brain Hypometabolism Hypothesis Part 23: GLUT1

glucose_2

Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century‘. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.

Addressing GLUT1, Thorens and Mueckler refer to this as the most intensively studied of this family.

GLUT1 is expressed in the endothelial cells that constitute the blood brain barrier. There is an emerging discussion about how GLUT1 specifically might be involved in neurodegenerative conditions such as Alzheimer’s Type Dementia (e.g. see this paper).

Appendix A – Citations

Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

Barros LF, San Martín A, Ruminot I, Sandoval PY, Fernández-Moncada I Baeza-Lehnert F, Arce-Molina R, Contreras-Baeza Y, Cortés-Molina F, Galaz A, Alegría K.J Neurosci Res. 2017 Feb 2. doi: 10.1002/jnr.23998. [Epub ahead of print]Near-critical GLUT1 and Neurodegeneration.

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

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Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section

The Colorado Health Information Exchange

The video above provides an overview of the Colorado Health Information Exchange – CORHIO (TM). What I found particularly instructive about this video was the discussion around the risk reduction and healthcare savings.

General Posts to Date on Health Information Exchanges

Posts on Examples of Health Information Exchanges

SNOMED CT®/ICD Mapping and Harmonisation Posts

SNOMED CT® Posts

ICD 1-10 Posts

ICD-11 Posts

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section

 

The Brain Hypometabolism Hypothesis Part 22: The Major Facilitator Superfamily (MFS) of membrane transporters

glucose_2

Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century‘.

In the article they note that the glucose transporters (members of the GLUT family) are part of the Major Facilitator Superfamily of Membrane Transporters (e.g. see this paper).

This superfamily of membrane transporters is responsible for transporting a large variety of compounds across the cell membrane and along an electrochemical gradient.

Appendix A – Citations

Pao SS, Paulsen IT, Saier MH. Major Facilitator Superfamily. Microbiology and Molecular Biology Reviews. 1998;62(1):1-34.
Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.

 

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section