Study Looks at Outcome in Depression Studies Published Before 1970 News Round-Up December 2013 3rd Edition

Researchers in this small 12-week trial of an SSRI in depression looked at grey matter volume at the beginning of the trial and cognitive and mood changes by the end of the trial. Subjects were aged 55 and over (n=34). The researchers found that a larger improvement in mood was associated with greater grey matter volume in several areas including the Cingulate gyrus as well as the superior and middle Frontal gyri.

This Cochrane trial looked at methods for retaining recruits to randomised trials. The reviewers concluded that incentives either after return of a completed questionnaire or with the questionnaire with a further incentive were the most effective methods for retaining recruits.

Researchers in this study looked at the outcome in mood disorders in the period before the widespread introduction of antidepressants, major tranquilisers and mood stabilisers. Subjects were follow up for between 1 and 30 years. The studies included 14,000 people and were published before 1970. The researchers had three main findings

1. Median rate of recovery was lower than in more recent studies

2. The time to recovery was longer than in more recent studies

3. The rate of recovery was higher than in more recent studies.

However there were methodological limitations. For instance antidepressants were introduced in the 1950’s and so this does not preclude the use of effective antidepressants in these older studies.

Atapuerca
Atapuerca

Appendix

News Round-Up 2008-2011

News Round-Up 2012

Index: There are indices for the TAWOP site here and here Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link. Podcast: You can listen to this post on Odiogo by clicking on this link (there may be a small delay between publishing of the blog article and the availability of the podcast). It is available for a limited period. TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link. Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk. Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog. Conflicts of Interest: For potential conflicts of interest please see the About section.

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