Cipriani and colleagues have recently published (open access, CC BY 4.0) another antidepressant meta-analysis. In this paper, Cipriani and colleagues look at 21 antidepressants (in their previous analysis they considered 12 antidepressants) and conclude that they are better than placebo and have a modest effect size in major depressive disorder in their analysis of the cited studies.
To give an idea of the amount of work involved in this research consider the following from the abstract
‘We identified 28 552 citations and of these included 522 trials comprising 116 477 participants‘
NHS Choices provide a very good overview here and also provide advice in response to the findings.
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