Myo-Inositol by Edgar181
What is Myo-Inositol?
Myo-Inositol is a molecule derived from Glucose-6-phosphate. Inositol is a substrate of GLUT 13 (one of the GLUT’s). Inositol plays a role in energy metabolism and is relevant to a discussion of the Brain Hypometabolism Hypothesis.
What are the GLUT’s?
GLUT’s are short for Glucose Transporters. They constitute a set of molecules which transport substrates across cell membranes. They play a central role in Glucose transport and hence the name. However their role is not limited to the transport of Glucose.
What is the Brain Hypometabolism Hypothesis?
The Brain Hypometabolism Hypothesis broadly states that
‘Hypometabolism in the brain leads to neuropathology‘
Human Metabolism by Evans Love (CC BY 4.0)
What is Metabolism?
Metabolism can be defined as the chemical processes that occur in living organisms. There are three types of metabolic processes
(a) Generation of energy
(b) Generation of basic chemicals including fatty acids, amino acids and sugars
(c) Elimination of Nitrogen waste products
Restating the Brain Hypometabolism Hypothesis
The Brain Hypometabolism Hypothesis focuses on energy metabolism. More specifically the hypothesis states that
‘Energy hypometabolism in the brain leads to neuropathology‘
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