Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century’. In terms of a Brain Hypometabolism Hypothesis, it is important to understand how Glucose is handled in the brain. Thorens and Mueckler reference 14 Glucose Transporters but not all of them are expressed in the brain.
In their paper, Professors Bernard Thorens and Mike Mueckler note that GLUT 14 is not primarily expressed in the brain and also that the role of GLUT 14 in glucose metabolism is not characterised.
What are the GLUT’s?
GLUT’s are short for Glucose Transporters. They constitute a set of molecules which transport substrates across cell membranes. They play a central role in Glucose transport and hence the name. However their role is not limited to the transport of Glucose.
What is the Brain Hypometabolism Hypothesis?
The Brain Hypometabolism Hypothesis broadly states that
‘Hypometabolism in the brain leads to neuropathology‘
What is Metabolism?
Metabolism can be defined as the chemical processes that occur in living organisms. There are three types of metabolic processes
(a) Generation of energy
(b) Generation of basic chemicals including fatty acids, amino acids and sugars
(c) Elimination of Nitrogen waste products
Restating the Brain Hypometabolism Hypothesis
The Brain Hypometabolism Hypothesis focuses on energy metabolism. More specifically the hypothesis states that
‘Energy hypometabolism in the brain leads to neuropathology‘
Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.
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