The ‘Brain Hypometabolism Hypothesis’ simply stated is that ‘Brain hypometabolism leads to neuropathology’. The hypothesis is more nuanced. In their 2016 paper, Cunnane and colleagues outline several supporting lines of evidence as the basis for their paper
(i) Lower glucose uptake in the frontal cortex of older adults
(ii) Regional deficits in brain glucose uptake in younger adults at risk of Alzheimer’s Type Dementia
(iii) Preservation of ketone uptake in the brain
(iv) Further evidence on consequences of ketone based interventions.
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