The Brain Hypometabolism Hypothesis: Part 5 – Setting the Scene. Brain Glucose Uptake


Cunnane and colleagues in their 2011 paper discuss the GLUT1 receptor which facilitates glucose uptake.

There are three separate isoforms of GLUT1 that facilitate glucose uptake in the brain

(1) One isoform facilitates glucose uptake across the blood-brain barrier

(2) Another isoform facilitates glucose uptake in astrocytes

(3) A third isoform facilitates glucose uptake in neurons

In their paper, Cunnane and colleagues note that the significance of the role of GLUT1 is still unclear as there were alternative mechanisms for glucose uptake.

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