The Brain Hypometabolism Hypothesis Part 22: The Major Facilitator Superfamily (MFS) of membrane transporters


Professors Bernard Thorens and Mike Mueckler have written a review titled ‘Glucose Transporters in the 21st Century‘.

In the article they note that the glucose transporters (members of the GLUT family) are part of the Major Facilitator Superfamily of Membrane Transporters (e.g. see this paper).

This superfamily of membrane transporters is responsible for transporting a large variety of compounds across the cell membrane and along an electrochemical gradient.

Appendix A – Citations

Pao SS, Paulsen IT, Saier MH. Major Facilitator Superfamily. Microbiology and Molecular Biology Reviews. 1998;62(1):1-34.
Thorens B, Mueckler M. Glucose transporters in the 21st Century. American Journal of Physiology – Endocrinology and Metabolism. 2010;298(2):E141-E145. doi:10.1152/ajpendo.00712.2009.


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