If there is a brain glucose hypometabolism in Alzheimer’s Type Dementia could this result directly from brain atrophy?
There is a specific research methodology that is able to answer this question – correction for atrophy. In their 2011 paper, Cunnane and colleagues review the literature on brain glucose metabolism studies in Alzheimer’s Type Dementia and summarise the results in Table 1 in the paper.
They note that in some studies, there is correction for atrophy and in those studies there is still a preservation of the relationship between Alzheimer’s Type Dementia and brain glucose hypometabolism.
The Brain Hypometabolism Hypothesis: Summary of Posts To Date
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