Daily Archives: February 3, 2017

VPS35 and Neurodegeneration

I was reviewing Small and Duff’s Dual Pathway Hypothesis relating to Alzheimer’s Disease and I focused on the Retromer Sorting Pathway. One component of the Retromer Complex is VPS35. The two researchers here describe a series of experiments which highlight the possible role of VPS35 in Parkinson’s Disease. In Small and Duff’s hypothesis, the VPS35 is related to the processing of Amyloid protein whilst in the model described above it is related to the processing of Alpha Synuclein.

Index: There are indices for the TAWOP site here and here

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Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

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ICD-4

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The fourth revision of Bertillon’s original classification of causes of death introduced some important developments. A copy of ICD-4 can be found at the WHO website. The publication is written in French and is 223 pages. Dr Jacques Bertillon headed previous revisions but had passed away in 1922. There is a further reference to the fourth revision of the international classification of the causes of death in this article at the WHO website. The conference for the fourth revision was held in 1929.

There were two important developments in the fourth revision

(1) The classification now included causes of morbidity as well as mortality

‘Nomenclatures International Des Maladies (Causes De Décès, Causes D’Incapacite De Travail)’

which via Google Translate is

‘International Nomenclature of Diseases (Causes of death, Causes of work disability)’

(2) The revision was a combined undertaking by the International Institute of Statistics and the Health Organisation of the League of Nations. The newly formed League of Nations followed the Paris Peace Conference and focused on establishing peace and stability after the events of World War 1.

The publication lists 200 causes of death and morbidity.

Appendix A – Other Posts in the Series on Health Information Exchanges

A Literature Review of 40 years of SNOMED

Arizona Statewide Health Information Exchange

A History of The Health Information Exchange in Pennsylvania

The Arkansas Health Information Exchange – SHARE

The California Health Information Exchange – Cal Index

Creating a Health Information Exchange in Arizona

Health Information Exchanges

Health Information Exchanges and Chronic Conditions

HIPPA and Health Information Exchanges

ICD-11 and SNOMED CT®

ICD-SNOMED-CT® Harmonisation

ICD-1 – Well…near enough

ICD-2

ICD-3

Körner Data and SNOMED: A Snapshot from 1988

Mapping ICD 9 (or 10) to SNOMED CT®

Over 1 Million Relationships: SNOMED CT ®

Standardisation of Health Information Technology in New Zealand

Statisticians were Responsible for the Development of an International Classification of Diseases

Why Do We Need Electronic Record Systems to Talk to Each Other

Appendix B – Definition of Health Information Exchange

This is the definition of the Health Information Exchange that I use (Hersh et al, 2015)

Health information exchange (HIE), the electronic sharing of clinical information across the boundaries of health care organizations

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.