VPS35 and Neurodegeneration

I was reviewing Small and Duff’s Dual Pathway Hypothesis relating to Alzheimer’s Disease and I focused on the Retromer Sorting Pathway. One component of the Retromer Complex is VPS35. The two researchers here describe a series of experiments which highlight the possible role of VPS35 in Parkinson’s Disease. In Small and Duff’s hypothesis, the VPS35 is related to the processing of Amyloid protein whilst in the model described above it is related to the processing of Alpha Synuclein.

Index: There are indices for the TAWOP site here and here

Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.

TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.

Responses: If you have any comments, you can leave them below or alternatively e-mail justinmarley17@yahoo.co.uk.

Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.

Conflicts of Interest: *For potential conflicts of interest please see the About section.

 

2 comments

  1. […] There was then a closer look at a component of the Retromer complex that was specifically mentioned in the DPH – VPs35. VPS35 was investigated in relation to Alzheimer’s Disease in a study published in 1995 by Small, one of the authors of the DPH. However much of the subsequent research into VPS35 has been related to Parkinson’s Disease and there has also been discussion of VPS35 more broadly in neurodegeneration. […]

    Like

  2. […] There was then a closer look at a component of the Retromer complex that was specifically mentioned in the DPH – VPs35. VPS35 was investigated in relation to Alzheimer’s Disease in a study published in 1995 by Small, one of the authors of the DPH. However much of the subsequent research into VPS35 has been related to Parkinson’s Disease and there has also been discussion of VPS35 more broadly in neurodegeneration. […]

    Like

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s