I was reviewing Small and Duff’s Dual Pathway Hypothesis relating to Alzheimer’s Disease and I focused on the Retromer Sorting Pathway. One component of the Retromer Complex is VPS35. The two researchers here describe a series of experiments which highlight the possible role of VPS35 in Parkinson’s Disease. In Small and Duff’s hypothesis, the VPS35 is related to the processing of Amyloid protein whilst in the model described above it is related to the processing of Alpha Synuclein.
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