I was reviewing Small and Duff’s Dual Pathway Hypothesis relating to Alzheimer’s Disease and I focused on the Retromer Sorting Pathway. One component of the Retromer Complex is VPS35. The two researchers here describe a series of experiments which highlight the possible role of VPS35 in Parkinson’s Disease. In Small and Duff’s hypothesis, the VPS35 is related to the processing of Amyloid protein whilst in the model described above it is related to the processing of Alpha Synuclein.
Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.
TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.
Responses: If you have any comments, you can leave them below or alternatively e-mail firstname.lastname@example.org.
Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.
Conflicts of Interest: *For potential conflicts of interest please see the About section.