I was reviewing Small and Duff’s Dual Pathway Hypothesis relating to Alzheimer’s Disease and I focused on the Retromer Sorting Pathway. One component of the Retromer Complex is VPS35. The two researchers here describe a series of experiments which highlight the possible role of VPS35 in Parkinson’s Disease. In Small and Duff’s hypothesis, the VPS35 is related to the processing of Amyloid protein whilst in the model described above it is related to the processing of Alpha Synuclein.
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The Amazing World of Psychiatry: A Psychiatry Blog 
[…] There was then a closer look at a component of the Retromer complex that was specifically mentioned in the DPH – VPs35. VPS35 was investigated in relation to Alzheimer’s Disease in a study published in 1995 by Small, one of the authors of the DPH. However much of the subsequent research into VPS35 has been related to Parkinson’s Disease and there has also been discussion of VPS35 more broadly in neurodegeneration. […]
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[…] There was then a closer look at a component of the Retromer complex that was specifically mentioned in the DPH – VPs35. VPS35 was investigated in relation to Alzheimer’s Disease in a study published in 1995 by Small, one of the authors of the DPH. However much of the subsequent research into VPS35 has been related to Parkinson’s Disease and there has also been discussion of VPS35 more broadly in neurodegeneration. […]
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