The Icelandic population has been closely studied in terms of the population genetics. This has led to many important discoveries about diseases. One of these discoveries is the Icelandic mutation A673T. The Icelandic mutation is a variant of the Amyloid precursor protein gene. The Amyloid Cascade Hypothesis is a central hypothesis in the pathogenesis of Alzheimer’s Disease. This mutation has been associated with less Amyloid deposition and with more resilience to cognitive decline in people with cerebral pathology. There is a useful overview at the Alzforum.
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