APOE4 and Mitochondria

DNA code analysis
In previous posts we looked at a review by Dose J, Huebbe P, Nebel A and Rimbach G titled  ‘APOE4 genotype and stress response – a mini review’. APOE4 is referenced as an upstream regulator of Tau and Amyloid pathology in Small and Duff’s Dual Pathway Hypothesis.
In their paper, Dose and colleagues note several lines of evidence that link APOE4 with  mitochondrial function either directly or indirectly
(1) Evidence that APOE4 binds to mitochondrial complexes III and IV
(2) Lower respiratory capacity in APOE4 models
(3) Low levels of brain glucose metabolism in APOE4 carriers
Many lines of evidence about this relationship are summarised in Table 2 in the paper.
Dose J, Huebbe P, Nebel A, Rimbach G. APOE genotype and stress response – a mini review. Lipids in Health and Disease. 2016;15:121. doi:10.1186/s12944-016-0288-2.

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